TY - JOUR
T1 - Biodegradable poly(butylene succinate) modified by gas plasmas and their in vitro functions as bone implants
AU - Wang, Huaiyu
AU - Xu, Ming
AU - Wu, Zhengwei
AU - Zhang, Wei
AU - Ji, Junhui
AU - Chu, Paul K.
PY - 2012/8/22
Y1 - 2012/8/22
N2 - Artificial implants are alternatives to autologous grafts in repairing severe bone damage and in many clinical applications, the artificial implant materials should be biodegradable in order to avoid chronic problems associated with biostable implants. In this study, a biodegradable biopolymer, poly(butylene succinate) (PBSu), is treated by N 2, NH 3 and H 2O plasmas and investigated as bone replacement materials in vitro to obtain a better understanding of the behavior of osteoblasts on the different plasma-treated materials. N 2, NH 3, and H 2O plasma immersion ion implantation (PIII) produces dominant C-N, C-N, and C-O surface functional groups, respectively rendering the materials with hydrophilic characteristics which favor osteoblast adhesion and early proliferation. In particular, N-containing groups, especially C-N, are more positive to osteogenic differentiation of the seeded osteoblasts than C-O. Among the 3 plasma treatments, NH 3 PIII is the most effective, yielding surface properties that are suitable for artificial bone implants. © 2012 American Chemical Society.
AB - Artificial implants are alternatives to autologous grafts in repairing severe bone damage and in many clinical applications, the artificial implant materials should be biodegradable in order to avoid chronic problems associated with biostable implants. In this study, a biodegradable biopolymer, poly(butylene succinate) (PBSu), is treated by N 2, NH 3 and H 2O plasmas and investigated as bone replacement materials in vitro to obtain a better understanding of the behavior of osteoblasts on the different plasma-treated materials. N 2, NH 3, and H 2O plasma immersion ion implantation (PIII) produces dominant C-N, C-N, and C-O surface functional groups, respectively rendering the materials with hydrophilic characteristics which favor osteoblast adhesion and early proliferation. In particular, N-containing groups, especially C-N, are more positive to osteogenic differentiation of the seeded osteoblasts than C-O. Among the 3 plasma treatments, NH 3 PIII is the most effective, yielding surface properties that are suitable for artificial bone implants. © 2012 American Chemical Society.
KW - cell adhesion and proliferation
KW - osteogenic differentiation
KW - plasma immersion ion implantation
KW - poly(butylene succinate)
KW - primary osteoblasts
KW - surface chemistry
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U2 - 10.1021/am301033t
DO - 10.1021/am301033t
M3 - RGC 21 - Publication in refereed journal
C2 - 22799540
SN - 1944-8244
VL - 4
SP - 4380
EP - 4386
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 8
ER -