Biodegradable Natural Product-Based Nanoparticles for Near-Infrared Fluorescence Imaging-Guided Sonodynamic Therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

9 Scopus Citations
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Author(s)

  • Xiuli Zheng
  • Weimin Liu
  • Jiechao Ge
  • Qingyan Jia
  • Fuchun Nan
  • Ying Ding
  • Jiasheng Wu
  • Pengfei Wang

Detail(s)

Original languageEnglish
Pages (from-to)18178-18185
Journal / PublicationACS Applied Materials and Interfaces
Volume11
Issue number20
Online published30 Apr 2019
Publication statusPublished - 22 May 2019

Abstract

Natural products show high potential for clinical translation because of their specific biological activities and molecular structure diversities. Sonosensitizers that originate from natural products play a crucial role as anti-inflammatory and anticancer agents. Herein, hypocrellin-derivative nanoparticles (APHB NPs) were constructed for synchronous near-infrared fluorescence (NIR FL) imaging and sonodynamic therapy (SDT) for deep-seated tumors in vivo. The prepared APHB NPs exhibit excellent water solubility, FL in the NIR region, and effective reactive oxygen species generation under ultrasound stimulation. Furthermore, the APHB NPs show excellent biocompatibility, suitable biodegradation rate, and enhanced tumor accumulation. Therefore, the APHB NPs exhibit promising clinical potential as novel safe and precise NIR FL imaging and SDT agents for deep-seated tumor therapy.

Research Area(s)

  • biodegradability, fluorescence imaging, natural product, sonodynamic therapy, sonosensitizer

Citation Format(s)

Biodegradable Natural Product-Based Nanoparticles for Near-Infrared Fluorescence Imaging-Guided Sonodynamic Therapy. / Zheng, Xiuli; Liu, Weimin; Ge, Jiechao; Jia, Qingyan; Nan, Fuchun; Ding, Ying; Wu, Jiasheng; Zhang, Wenjun; Lee, Chun-Sing; Wang, Pengfei.

In: ACS Applied Materials and Interfaces, Vol. 11, No. 20, 22.05.2019, p. 18178-18185.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal