Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

Xiaozhen Li; Lu Liu; Shengliang Li; Yingpeng Wan; Jia-Xiong Chen; Shuang Tian; Zhongming Huang; Ya-Fang Xiao; Xiao Cui; Chengyang Xiang; Qinglong Tan; Xiao-Hong Zhang; Weisheng Guo; Xing-Jie Liang; Chun-Sing Lee

doi:10.1021/acsnano.9b05383

Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

Xiaozhen Li
, Lu Liu
, Shengliang Li^*
, Yingpeng Wan
, Jia-Xiong Chen
, Shuang Tian
, Zhongming Huang
, Ya-Fang Xiao
, Xiao Cui
, Chengyang Xiang
, Qinglong Tan
, Xiao-Hong Zhang
, Weisheng Guo^*
, Xing-Jie Liang
, Chun-Sing Lee^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

237 Citations (Scopus)

Abstract

We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.

Original language	English
Pages (from-to)	12901-12911
Journal	ACS Nano
Volume	13
Issue number	11
Online published	4 Nov 2019
DOIs	https://doi.org/10.1021/acsnano.9b05383
Publication status	Published - 26 Nov 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

biodegradability
conjugated oligomer
nanoparticle
photothermal conversion efficiency
photothermal therapy

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10.1021/acsnano.9b05383

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@article{5914f91f5136487982a7d33046b2708a,

title = "Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics",

abstract = "We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82\%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.",

keywords = "biodegradability, conjugated oligomer, nanoparticle, photothermal conversion efficiency, photothermal therapy",

author = "Xiaozhen Li and Lu Liu and Shengliang Li and Yingpeng Wan and Jia-Xiong Chen and Shuang Tian and Zhongming Huang and Ya-Fang Xiao and Xiao Cui and Chengyang Xiang and Qinglong Tan and Xiao-Hong Zhang and Weisheng Guo and Xing-Jie Liang and Chun-Sing Lee",

year = "2019",

month = nov,

day = "26",

doi = "10.1021/acsnano.9b05383",

language = "English",

volume = "13",

pages = "12901--12911",

journal = "ACS Nano",

issn = "1936-0851",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

AU - Li, Xiaozhen

AU - Liu, Lu

AU - Li, Shengliang

AU - Wan, Yingpeng

AU - Chen, Jia-Xiong

AU - Tian, Shuang

AU - Huang, Zhongming

AU - Xiao, Ya-Fang

AU - Cui, Xiao

AU - Xiang, Chengyang

AU - Tan, Qinglong

AU - Zhang, Xiao-Hong

AU - Guo, Weisheng

AU - Liang, Xing-Jie

AU - Lee, Chun-Sing

PY - 2019/11/26

Y1 - 2019/11/26

N2 - We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.

AB - We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.

KW - biodegradability

KW - conjugated oligomer

KW - nanoparticle

KW - photothermal conversion efficiency

KW - photothermal therapy

UR - https://www.scopus.com/pages/publications/85075025235

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85075025235&origin=recordpage

U2 - 10.1021/acsnano.9b05383

DO - 10.1021/acsnano.9b05383

M3 - RGC 21 - Publication in refereed journal

SN - 1936-0851

VL - 13

SP - 12901

EP - 12911

JO - ACS Nano

JF - ACS Nano

IS - 11

ER -

Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

Abstract

UN SDGs

Research Keywords

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