Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Pages (from-to) | 12901-12911 |
Journal / Publication | ACS Nano |
Volume | 13 |
Issue number | 11 |
Online published | 4 Nov 2019 |
Publication status | Published - 26 Nov 2019 |
Link(s)
Abstract
We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.
Research Area(s)
- biodegradability, conjugated oligomer, nanoparticle, photothermal conversion efficiency, photothermal therapy
Citation Format(s)
Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics. / Li, Xiaozhen; Liu, Lu; Li, Shengliang et al.
In: ACS Nano, Vol. 13, No. 11, 26.11.2019, p. 12901-12911.
In: ACS Nano, Vol. 13, No. 11, 26.11.2019, p. 12901-12911.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review