Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

Xiaozhen Li; Lu Liu; Shengliang Li; Yingpeng Wan; Jia-Xiong Chen; Shuang Tian; Zhongming Huang; Ya-Fang Xiao; Xiao Cui; Chengyang Xiang; Qinglong Tan; Xiao-Hong Zhang; Weisheng Guo; Xing-Jie Liang; Chun-Sing Lee

doi:10.1021/acsnano.9b05383

Author(s)

Lu Liu
Shengliang Li
Jia-Xiong Chen
Xiao Cui
Chengyang Xiang
Qinglong Tan
Xiao-Hong Zhang
Weisheng Guo
Xing-Jie Liang
Chun-Sing Lee

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	12901-12911
Journal / Publication	ACS Nano
Volume	13
Issue number	11
Online published	4 Nov 2019
Publication status	Published - 26 Nov 2019

Link(s)

DOI	DOI https://doi.org/10.1021/acsnano.9b05383 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85075025235&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(5914f91f-5136-4879-82a7-d33046b2708a).html

Abstract

We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.

Research Area(s)

biodegradability, conjugated oligomer, nanoparticle, photothermal conversion efficiency, photothermal therapy

SDG 3 - Good Health and Well-being

Citation Format(s)

[ RIS ] [ BibTeX ]

Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics. / Li, Xiaozhen; Liu, Lu; Li, Shengliang et al.
In: ACS Nano, Vol. 13, No. 11, 26.11.2019, p. 12901-12911.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Li, X, Liu, L, Li, S, Wan, Y, Chen, J-X, Tian, S , Huang, Z , Xiao, Y-F , Cui, X, Xiang, C, Tan, Q, Zhang, X-H, Guo, W, Liang, X-J & Lee, C-S 2019, 'Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics', ACS Nano, vol. 13, no. 11, pp. 12901-12911. https://doi.org/10.1021/acsnano.9b05383

Li, X., Liu, L., Li, S., Wan, Y., Chen, J.-X., Tian, S., Huang, Z., Xiao, Y.-F., Cui, X., Xiang, C., Tan, Q., Zhang, X.-H., Guo, W., Liang, X.-J., & Lee, C.-S. (2019). Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics. ACS Nano, 13(11), 12901-12911. https://doi.org/10.1021/acsnano.9b05383

Li X, Liu L, Li S, Wan Y, Chen JX, Tian S et al. Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics. ACS Nano. 2019 Nov 26;13(11):12901-12911. Epub 2019 Nov 4. doi: 10.1021/acsnano.9b05383

Li, Xiaozhen ; Liu, Lu ; Li, Shengliang et al. / Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics. In: ACS Nano. 2019 ; Vol. 13, No. 11. pp. 12901-12911.