Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Lu Liu
  • Shengliang Li
  • Jia-Xiong Chen
  • Xiao Cui
  • Chengyang Xiang
  • Qinglong Tan
  • Xiao-Hong Zhang
  • Weisheng Guo
  • Xing-Jie Liang
  • Chun-Sing Lee

Detail(s)

Original languageEnglish
Pages (from-to)12901-12911
Journal / PublicationACS Nano
Volume13
Issue number11
Online published4 Nov 2019
Publication statusPublished - 26 Nov 2019

Abstract

We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.

Research Area(s)

  • biodegradability, conjugated oligomer, nanoparticle, photothermal conversion efficiency, photothermal therapy

Citation Format(s)

Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics. / Li, Xiaozhen; Liu, Lu; Li, Shengliang; Wan, Yingpeng; Chen, Jia-Xiong; Tian, Shuang; Huang, Zhongming; Xiao, Ya-Fang; Cui, Xiao; Xiang, Chengyang; Tan, Qinglong; Zhang, Xiao-Hong; Guo, Weisheng; Liang, Xing-Jie; Lee, Chun-Sing.

In: ACS Nano, Vol. 13, No. 11, 26.11.2019, p. 12901-12911.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review