Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

  • Jundong Shao
  • Hanhan Xie
  • Hao Huang
  • Zhibin Li
  • Zhengbo Sun
  • Yanhua Xu
  • Quanlan Xiao
  • Xue-Feng Yu
  • Yuetao Zhao
  • Han Zhang
  • Huaiyu Wang

Detail(s)

Original languageEnglish
Article number12967
Journal / PublicationNature Communications
Volume7
Publication statusPublished - 30 Sep 2016

Link(s)

Abstract

Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The in vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination. These BP-based nanospheres combine biodegradability and biocompatibility with high PTT efficiency, thus promising high clinical potential.

Research Area(s)

Citation Format(s)

Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy. / Shao, Jundong; Xie, Hanhan; Huang, Hao; Li, Zhibin; Sun, Zhengbo; Xu, Yanhua; Xiao, Quanlan; Yu, Xue-Feng; Zhao, Yuetao; Zhang, Han; Wang, Huaiyu; Chu, Paul K.

In: Nature Communications, Vol. 7, 12967, 30.09.2016.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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