Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Qiangwei Wang
  • Xianfeng Wang
  • Yongyong Guo
  • James Chung-Wah Lam
  • Bingsheng Zhou

Detail(s)

Original languageEnglish
Pages (from-to)5123-5132
Journal / PublicationEnvironmental Science and Technology
Volume49
Issue number8
Online published9 Apr 2015
Publication statusPublished - 21 Apr 2015

Abstract

Organophosphate flame retardants are emerging environmental contaminants, although knowledge of their health risks is limited. Here, thyroid hormone homeostasis and neuronal development was studied in the progeny of adult zebrafish exposed to tris(1,3-dichloro-2-propyl) phosphate (TDCPP). Adult zebrafish were exposed to TDCPP (0, 4, 20, and 100 μg/L) for 3 months. Increased generation of reactive oxygen species and reduced survival rates was observed in exposed F1 larvae. We also observed a significant decrease in plasma thyroxine and 3,5,3′-triiodothyronine levels in F0 females and F1 eggs/larvae. The mRNA and protein expression of factors associated with neuronal development (e.g., α1-tubulin, myelin basic protein, and synapsin IIa) were significantly downregulated in exposed F1 larvae, as was the level of the neurotransmitters dopamine, serotonin, gamma amino butyric acid, and histamine. Larval locomotion was significantly decreased in exposed fish, but there was no effect on acetylcholinesterase activity. Bioconcentration of TDCPP was observed in F0 fish. TDCPP was also detected in F1 eggs following parental exposure, indicating maternal transfer of this compound. This study uniquely shows that TDCPP can be transferred to the offspring of exposed adults, causing thyroid endocrine disruption and developmental neurotoxicity.

Citation Format(s)

Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae. / Wang, Qiangwei; Lai, Nelson Lok-Shun; Wang, Xianfeng; Guo, Yongyong; Lam, Paul Kwan-Sing; Lam, James Chung-Wah; Zhou, Bingsheng.

In: Environmental Science and Technology, Vol. 49, No. 8, 21.04.2015, p. 5123-5132.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal