Abstract
Epstein-Barr virus (EBV) is a common human-infected virus related to many diseases and cancers. Recently, some peptides have been found to serve targeting and therapeutic roles by inhibiting EBNA1, an oncoprotein of the EBV. We herein report the conjugation of the EBNA1-targeting peptides and porphyrins which can bring synergistic effects by both introducing more specific treatments (photodynamic therapy) and improving the biocompatibility of the photosensitizer and the peptides. One of our compounds exhibited significant photo-cytotoxicity where the Lethal Concentration 50 (LC50)=6.1 μM in EBV-positive cells. Besides, in vitro cell imaging and co-staining can also be achieved simultaneously and suggested the binding inside nucleus. © 2022 Wiley-VCH GmbH.
| Original language | English |
|---|---|
| Article number | e202200184 |
| Journal | ChemPlusChem |
| Volume | 87 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2022 |
| Externally published | Yes |
Funding
Financial assistance from the Hong Kong Research Grants Council Grant No. 1230019, Dr. Mok Man Hung Endowed Professorship in Chemistry, HKBU – Durham Lanthanide Joint Research Center – Lanthanide, and from Health and Medical Research Fund 2019/2020 (18170022). Tools for Systems Medicine (SDF19-1011-P02) and the Centre for Medical Engineering of Molecular and Biological Probes (AoE/M-401/20) are gratefully acknowledged (K.-L.W.).
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Research Keywords
- cell imaging
- Epstein-Barr virus
- photodynamic therapy
- porphyrin
- singlet oxygen
RGC Funding Information
- RGC-funded
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