Biocompatible Light Guide-Assisted Wearable Devices for Enhanced UV Light Delivery in Deep Skin

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
View graph of relations

Author(s)

  • Hao Zhang
  • Hangbo Zhao
  • Xingyue Zhao
  • Chenkai Xu
  • Daniel Franklin
  • Abraham Vázquez-Guardado
  • Wubin Bai
  • Jeffrey Zhao
  • Kan Li
  • Giuditta Monti
  • Wei Lu
  • Aya Kobeissi
  • Limei Tian
  • Xin Ning
  • Sunita Mehta
  • Debashis Chanda
  • Yonggang Huang
  • Shuai Xu
  • Bethany E. Perez White
  • John A. Rogers

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number2100576
Journal / PublicationAdvanced Functional Materials
Volume31
Issue number23
Online published31 Mar 2021
Publication statusPublished - 2 Jun 2021

Abstract

Phototherapy represents an attractive route for treating a range of challenging dermatological diseases. Existing skin phototherapy modalities rely on direct UV illumination, although with limited efficacy in addressing disorders of deeper tissue and with requirements for specialized illumination equipment and masks to shield unaffected regions of the skin. This work introduces a skin-integrated optoelectronic device that incorporates an array of UVA (360 nm) light emitting diodes in layouts that match those of typical lesional plaques and in designs that couple to biocompatible, penetrating polymer microneedle light waveguides to provide optical access to deep skin. Monte Carlo simulations and experimental results in phantom skin suggest that these waveguides significantly enhance light delivery to deep skin, with a >4-fold increase for depths of >500 µm. In ex vivo human skin, the devices show reduced measures of phototoxicity compared to direct illumination and enhanced modulation of gene expression relevant to sclerosing skin diseases. These systems are also compatible with design principles in soft, skin-compatible electronics and battery-powered wireless operation. Collectively, the favorable mechanical and light delivery properties of these devices expand possibilities in targeting of deep skin lesions beyond those attainable with clinical-standard UV light therapy approaches.

Research Area(s)

  • biocompatible microneedles, light waveguides, skin phototherapy, wearable devices

Citation Format(s)

Biocompatible Light Guide-Assisted Wearable Devices for Enhanced UV Light Delivery in Deep Skin. / Zhang, Hao; Zhao, Hangbo; Zhao, Xingyue; Xu, Chenkai; Franklin, Daniel; Vázquez-Guardado, Abraham; Bai, Wubin; Zhao, Jeffrey; Li, Kan; Monti, Giuditta; Lu, Wei; Kobeissi, Aya; Tian, Limei; Ning, Xin; Yu, Xinge; Mehta, Sunita; Chanda, Debashis; Huang, Yonggang; Xu, Shuai; Perez White, Bethany E.; Rogers, John A.

In: Advanced Functional Materials, Vol. 31, No. 23, 2100576, 02.06.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review