Biocompatibility study on Ni-free Ti-based and Zr-based bulk metallic glasses

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • T.H. Li
  • P.C. Wong
  • S.F. Chang
  • P.H. Tsai
  • J.S.C. Jang

Detail(s)

Original languageEnglish
Pages (from-to)1-6
Journal / PublicationMaterials Science and Engineering C
Volume75
Online published9 Feb 2017
Publication statusPublished - 1 Jun 2017
Externally publishedYes

Abstract

Safety and reliability are crucial issues for medical instruments and implants. In the past few decays, bulk metallic glasses (BMGs) have drawn attentions due to their superior mechanical properties, good corrosion resistance, antibacterial and good biocompatibility. However, most Zr-based and Ti-based BMGs contain Ni as an important element which is prone to human allergy problem. In this study, the Ni-free Ti-based and Zr-based BMGs, Ti40Zr10Cu36Pd14, and Zr48Cu36Al8Ag8, were selected for systematical evaluation of their biocompatibility. Several biocompatibility tests, co-cultural with L929 murine fibroblast cell line, were carried out on these two BMGs, as well as the comparison samples of Ti6Al4V and pure Cu. The results in terms of cellular adhesion, cytotoxicity, and metallic ion release affection reveal that the Ti40Zr10Cu36Pd14 BMG and Ti6Al4V exhibit the optimum biocompatibility; cells still being attached on the petri dish with good adhesion and exhibiting the spindle shape after direct contact test. Furthermore, the Ti40Zr10Cu36Pd14 BMG showed very low Cu ion release level, in agreement with the MTT results. Based on the current findings, it is believed that Ni-free Ti-based BMG can act as an ideal candidate for medical implant.

Research Area(s)

  • Biocompatibility, Bulk metallic glass, L929 murine fibroblast cell line, MTT

Citation Format(s)

Biocompatibility study on Ni-free Ti-based and Zr-based bulk metallic glasses. / Li, T.H.; Wong, P.C.; Chang, S.F. et al.
In: Materials Science and Engineering C, Vol. 75, 01.06.2017, p. 1-6.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review