Abstract
Here we report the synthesis of uniform silica coated hexagonal-phase NaYF4 nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF4 nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF4 upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems. © 2008 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 4122-4128 |
| Journal | Biomaterials |
| Volume | 29 |
| Issue number | 30 |
| DOIs | |
| Publication status | Published - Oct 2008 |
| Externally published | Yes |
Bibliographical note
Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].Funding
We acknowledge the financial support from Singapore A*STAR BMRC (grant number R397-000-624-305) and National University of Singapore. We also thank Dr. Zhengquan Li for synthesis of the nanoparticles.
Research Keywords
- Biodistribution
- Imaging
- Near infrared
- Toxicity
- Upconversion nanocrystals
Fingerprint
Dive into the research topics of 'Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver