Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals

Rufaihah Abdul Jalil; Yong Zhang

doi:10.1016/j.biomaterials.2008.07.012

Biocompatibility of silica coated NaYF₄ upconversion fluorescent nanocrystals

Rufaihah Abdul Jalil, Yong Zhang

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

494 Citations (Scopus)

Abstract

Here we report the synthesis of uniform silica coated hexagonal-phase NaYF₄ nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF₄ nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF₄ upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems. © 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	4122-4128
Journal	Biomaterials
Volume	29
Issue number	30
DOIs	https://doi.org/10.1016/j.biomaterials.2008.07.012
Publication status	Published - Oct 2008
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

Biodistribution
Imaging
Near infrared
Toxicity
Upconversion nanocrystals

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Cite this

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title = "Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals",

abstract = "Here we report the synthesis of uniform silica coated hexagonal-phase NaYF4 nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF4 nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF4 upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems. {\textcopyright} 2008 Elsevier Ltd. All rights reserved.",

keywords = "Biodistribution, Imaging, Near infrared, Toxicity, Upconversion nanocrystals",

author = "{Abdul Jalil}, Rufaihah and Yong Zhang",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected]. ",

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TY - JOUR

T1 - Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals

AU - Abdul Jalil, Rufaihah

AU - Zhang, Yong

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2008/10

Y1 - 2008/10

N2 - Here we report the synthesis of uniform silica coated hexagonal-phase NaYF4 nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF4 nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF4 upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems. © 2008 Elsevier Ltd. All rights reserved.

AB - Here we report the synthesis of uniform silica coated hexagonal-phase NaYF4 nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF4 nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF4 upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems. © 2008 Elsevier Ltd. All rights reserved.

KW - Biodistribution

KW - Imaging

KW - Near infrared

KW - Toxicity

KW - Upconversion nanocrystals

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U2 - 10.1016/j.biomaterials.2008.07.012

DO - 10.1016/j.biomaterials.2008.07.012

M3 - RGC 21 - Publication in refereed journal

C2 - 18675453

SN - 0142-9612

VL - 29

SP - 4122

EP - 4128

JO - Biomaterials

JF - Biomaterials

IS - 30

ER -