Bioactive SrTiO3 nanotube arrays : Strontium delivery platform on Ti-based osteoporotic bone implants

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)3228-3234
Journal / PublicationACS Nano
Volume3
Issue number10
Publication statusPublished - 27 Oct 2009

Abstract

Development of strontium releasing implants capable of stimulating bone formation and inhibiting bone resorption is a desirable solution for curing osteoporosis. In this work, well-ordered SrTiO3 nanotube arrays capable of Sr release at a slow rate and for a long time are successfully fabricated on titanium by simple hydrothermal treatmentofanodized titania nanotubes. This surface architecture combines the functions of nanoscaled topography and Sr release to enhance osseointegration while at the same time leaving space for loading of other functional substances. In vitro experiments reveal that the SrTiO3 nanotube arrays possess good biocompatibility and can induce precipitation of hydroxyapatite from simulated body fluids (SBF). This Ti-based implant with SrTiO3 nanotube arrays is an ideal candidate for osteoporotic bone implants. The proposed method can also be extended to load other biologically useful elements such as Mg and Zn. © 2009 American Chemical Society.

Research Area(s)

  • Bioactivity, Osteoporosis, SrTiO3 nanotube arrays, Strontium

Citation Format(s)

Bioactive SrTiO3 nanotube arrays : Strontium delivery platform on Ti-based osteoporotic bone implants. / Xin, Yunchang; Jiang, Jiang; Huo, Kaifu; Hu, Tao; Chu, Paul K.

In: ACS Nano, Vol. 3, No. 10, 27.10.2009, p. 3228-3234.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review