Bioactive compounds with anti-oxidative and anti-inflammatory activities of hop extracts

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Chun-Nan Wu
  • Li-Chin Sun
  • Yung-Lin Chu
  • Roch-Chui Yu
  • Chang-Wei Hsieh
  • Fu-Chiun Hsu
  • Kuan-Chen Cheng

Detail(s)

Original languageEnglish
Article number127244
Number of pages8
Journal / PublicationFood Chemistry
Volume330
Online published3 Jun 2020
Publication statusPublished - 15 Nov 2020

Abstract

The aim of this study is to simultaneously evaluate anti-oxidative and anti-inflammatory activities of the hop extracts by different solvents. Hop water extract (HWE) and hop ethanol extracts (HEEs) were prepared by extracting hop pellets with hot water at 90 °C and ethanol solutions (55%, 75%, and 95%), respectively. Bioactive compound such as α-acid, β-acid, total phenolic, and total flavonoid contents were determined. All the HEEs showed higher anti-oxidative activities than the HWEs. The HEEs showing the highest anti-oxidative activities are different in the experiments with different free radicals. For anti-inflammatory activities, both the HWE and HEEs decreased NO productions. HWE decreased TNF-α and IL-6 secretion but showed no effect on IL-1β, while HEEs decreased IL-1β and IL-6 secretion but increased TNF-α secretion. Except for TNF-α secretion, the HEEs showed higher anti-inflammatory activities than the HWE. Future work is to explore the possible mechanism to improve the ethanol extraction procedure.

Research Area(s)

  • Hop, Humulus lupulus, Anti-oxidation, Anti-inflammation, Proinflammatory cytokine

Citation Format(s)

Bioactive compounds with anti-oxidative and anti-inflammatory activities of hop extracts. / Wu, Chun-Nan; Sun, Li-Chin; Chu, Yung-Lin et al.
In: Food Chemistry, Vol. 330, 127244, 15.11.2020.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review