Bio-tribological properties and cytocompatibility of Ti-Si-N coatings

Ming Zhang; Shengli Ma; Kewei Xu; Long Bai; Paul K. Chu

doi:10.1016/j.vacuum.2015.02.012

Bio-tribological properties and cytocompatibility of Ti-Si-N coatings

Ming Zhang, Shengli Ma, Kewei Xu, Long Bai, Paul K. Chu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

13 Citations (Scopus)

Abstract

Ti-Si-N coatings are synthesized on titanium alloy (Ti₆Al₄V) by arc-enhanced magnetron sputtering and the microstructure and tribological properties are determined. The friction coefficient of the Ti-Si-N coatings, which is smaller in human serum than ambient air, decreases gradually with Si contents. Protein gel electrophoresis shows that the small friction coefficient is due to adsorbed proteins from the human serum under sliding conditions. The cytocompatibility of the coatings is assessed in vitro by a relative nitrite assay. The Ti-Si-N coatings have a positive effect on nitric oxide synthesis on the endothelial cells. The cell morphology and spreading on the coatings are examined by fluorescence staining. The Ti-Si-N coating with 12 at% Si exhibits the best effects in promoting actin cytoskeleton formation and cell spreading compared to coatings with different Si contents and titanium alloy.

Original language	English
Pages (from-to)	50-57
Journal	Vacuum
Volume	115
DOIs	https://doi.org/10.1016/j.vacuum.2015.02.012
Publication status	Published - May 2015

Research Keywords

Bio-tribological properties
Cytocompatibility
Ti-Si-N coatings

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10.1016/j.vacuum.2015.02.012

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@article{7aa9762dc7a64f94bc1902d2f364991a,

title = "Bio-tribological properties and cytocompatibility of Ti-Si-N coatings",

abstract = "Ti-Si-N coatings are synthesized on titanium alloy (Ti6Al4V) by arc-enhanced magnetron sputtering and the microstructure and tribological properties are determined. The friction coefficient of the Ti-Si-N coatings, which is smaller in human serum than ambient air, decreases gradually with Si contents. Protein gel electrophoresis shows that the small friction coefficient is due to adsorbed proteins from the human serum under sliding conditions. The cytocompatibility of the coatings is assessed in vitro by a relative nitrite assay. The Ti-Si-N coatings have a positive effect on nitric oxide synthesis on the endothelial cells. The cell morphology and spreading on the coatings are examined by fluorescence staining. The Ti-Si-N coating with 12 at% Si exhibits the best effects in promoting actin cytoskeleton formation and cell spreading compared to coatings with different Si contents and titanium alloy.",

keywords = "Bio-tribological properties, Cytocompatibility, Ti-Si-N coatings",

author = "Ming Zhang and Shengli Ma and Kewei Xu and Long Bai and Chu, {Paul K.}",

year = "2015",

month = may,

doi = "10.1016/j.vacuum.2015.02.012",

language = "English",

volume = "115",

pages = "50--57",

journal = "Vacuum",

issn = "0042-207X",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Bio-tribological properties and cytocompatibility of Ti-Si-N coatings

AU - Zhang, Ming

AU - Ma, Shengli

AU - Xu, Kewei

AU - Bai, Long

AU - Chu, Paul K.

PY - 2015/5

Y1 - 2015/5

N2 - Ti-Si-N coatings are synthesized on titanium alloy (Ti6Al4V) by arc-enhanced magnetron sputtering and the microstructure and tribological properties are determined. The friction coefficient of the Ti-Si-N coatings, which is smaller in human serum than ambient air, decreases gradually with Si contents. Protein gel electrophoresis shows that the small friction coefficient is due to adsorbed proteins from the human serum under sliding conditions. The cytocompatibility of the coatings is assessed in vitro by a relative nitrite assay. The Ti-Si-N coatings have a positive effect on nitric oxide synthesis on the endothelial cells. The cell morphology and spreading on the coatings are examined by fluorescence staining. The Ti-Si-N coating with 12 at% Si exhibits the best effects in promoting actin cytoskeleton formation and cell spreading compared to coatings with different Si contents and titanium alloy.

AB - Ti-Si-N coatings are synthesized on titanium alloy (Ti6Al4V) by arc-enhanced magnetron sputtering and the microstructure and tribological properties are determined. The friction coefficient of the Ti-Si-N coatings, which is smaller in human serum than ambient air, decreases gradually with Si contents. Protein gel electrophoresis shows that the small friction coefficient is due to adsorbed proteins from the human serum under sliding conditions. The cytocompatibility of the coatings is assessed in vitro by a relative nitrite assay. The Ti-Si-N coatings have a positive effect on nitric oxide synthesis on the endothelial cells. The cell morphology and spreading on the coatings are examined by fluorescence staining. The Ti-Si-N coating with 12 at% Si exhibits the best effects in promoting actin cytoskeleton formation and cell spreading compared to coatings with different Si contents and titanium alloy.

KW - Bio-tribological properties

KW - Cytocompatibility

KW - Ti-Si-N coatings

UR - http://www.scopus.com/inward/record.url?scp=84923322854&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84923322854&origin=recordpage

U2 - 10.1016/j.vacuum.2015.02.012

DO - 10.1016/j.vacuum.2015.02.012

M3 - RGC 21 - Publication in refereed journal

SN - 0042-207X

VL - 115

SP - 50

EP - 57

JO - Vacuum

JF - Vacuum

ER -

Bio-tribological properties and cytocompatibility of Ti-Si-N coatings

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