Bimodal optical diagnostics of oral cancer based on Rose Bengal conjugated gold nanorod platform

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

63 Scopus Citations
View graph of relations

Author(s)

  • Jia-Hong Wang
  • Beike Wang
  • Qian Liu
  • Qian Li
  • Hao Huang
  • Li Song
  • Tian-Ying Sun
  • Huaiyu Wang
  • Xue-Feng Yu
  • Chengzhang Li

Detail(s)

Original languageEnglish
Pages (from-to)4274-4283
Journal / PublicationBiomaterials
Volume34
Issue number17
Publication statusPublished - Jun 2013

Abstract

Early detection of cancer often requires time consuming protocols and expensive instrumentation. To address these limitations, a Rose Bengal conjugated gold nanorod (RB-GNR) platform is developed for optical detection of cancer cells. The GNRs are modified by poly(allylamine hydrochloride) and conjugated with RB molecules to produce RB-GNRs which exhibit strong optical absorption in the near-infrared (NIR) region, good stability in aqueous solution, low cytotoxicity, and high specificity to oral cancer cells. The label-free sensing assay utilizes RB-GNRs as the sensing probe and by monitoring the aggregation-induced red-shift in the NIR absorption wavelength, specific and quantitative analysis of the oral cancer cell lysate is accomplished down to a detection limit of 2000 cells/mL. By employing the RB-GNRs as an imaging probe, an imaging assay is established on a home-made NIR absorption imaging system. Based on the NIR absorption by the RB-GNRs specifically conjugated with the oral cancer cells, multi-channel, rapid and quantitative detection of oral cancer cells is demonstrated. The high sensitivity and specificity of the RB-GNR platform as demonstrated by the two complementary assays provide non-invasive optical diagnostics of oral cancer cells enabling convenient screening and monitoring. © 2013 Elsevier Ltd.

Research Area(s)

  • Absorption imaging, Biosensors, Gold nanorods, Optical diagnostics, Oral cancer, Rose Bengal

Citation Format(s)

Bimodal optical diagnostics of oral cancer based on Rose Bengal conjugated gold nanorod platform. / Wang, Jia-Hong; Wang, Beike; Liu, Qian; Li, Qian; Huang, Hao; Song, Li; Sun, Tian-Ying; Wang, Huaiyu; Yu, Xue-Feng; Li, Chengzhang; Chu, Paul K.

In: Biomaterials, Vol. 34, No. 17, 06.2013, p. 4274-4283.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review