TY - GEN
T1 - Bilateral lesions of pontine k̈lliker-fuse nuclei provoke apnea instead of apneusis in anesthetized adult rats
AU - Song, Gang
AU - Tin, Chung
AU - Poon, Chi-Sang
PY - 2010
Y1 - 2010
N2 - The K̈lliker-Fuse nucleus (KF) has been traditionally dubbed the "pneumotaxic center". Here, we report that lesions of KF nuclei of bilateral pons caused apnea (complete cessation of phrenic discharge) instead of apneusis in urethane-anesthetized, vagotomized, paralyzed and ventilated adult rats. After bilateral lesions of KF nuclei with the neuroexcitotoxin kainic acid, phrenic discharge disappeared and no spontaneous recovery of phrenic discharge was observed for up to 3 hours. During the apnea, hypoxia or hypercapnia provoked transient rhythmic phrenic discharge. The present finding showed that the KF nucleus not only directly participates in inspiratory to expiratory phase switching, but also provides a vital excitatory drive that is requisite for the generation of inspiratory activity. © Springer Science+Business Media, LLC 2010.
AB - The K̈lliker-Fuse nucleus (KF) has been traditionally dubbed the "pneumotaxic center". Here, we report that lesions of KF nuclei of bilateral pons caused apnea (complete cessation of phrenic discharge) instead of apneusis in urethane-anesthetized, vagotomized, paralyzed and ventilated adult rats. After bilateral lesions of KF nuclei with the neuroexcitotoxin kainic acid, phrenic discharge disappeared and no spontaneous recovery of phrenic discharge was observed for up to 3 hours. During the apnea, hypoxia or hypercapnia provoked transient rhythmic phrenic discharge. The present finding showed that the KF nucleus not only directly participates in inspiratory to expiratory phase switching, but also provides a vital excitatory drive that is requisite for the generation of inspiratory activity. © Springer Science+Business Media, LLC 2010.
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U2 - 10.1007/978-1-4419-5692-7_37
DO - 10.1007/978-1-4419-5692-7_37
M3 - RGC 32 - Refereed conference paper (with host publication)
C2 - 20217346
SN - 9781441956910
VL - 669
T3 - Advances in Experimental Medicine and Biology
SP - 185
EP - 188
BT - New Frontiers in Respiratory Control: XIth Annual Oxford Conference on Modeling and Control of Breathing
ER -