TY - JOUR
T1 - Beyond the silence
T2 - A comprehensive exploration of long non-coding RNAs as genetic whispers and their essential regulatory functions in cardiovascular disorders
AU - Xiong, Yuchen
AU - Aloud, Mohammed A.H.
AU - Ali, Hamid
AU - Ali, Ijaz
AU - Ahmad, Saleem
AU - Khan, Munir Ullah
AU - Hassan, Syed Shams ul
AU - Majid, Muhammad
AU - Khan, Muhammad Shehzad
AU - Ahmad, Rafi u Shan
AU - Khan, Shahid Ullah
AU - Khan, Khalid Ali
AU - White, Alexandra
PY - 2024/3
Y1 - 2024/3
N2 - Long non-coding RNAs (lncRNAs) are RNA molecules that regulate gene expression at several levels, including transcriptional, post-transcriptional, and translational. They have a length of more than 200 nucleotides and cannot code. Many human diseases have been linked to aberrant lncRNA expression, highlighting the need for a better knowledge of disease etiology to drive improvements in diagnostic, prognostic, and therapeutic methods. Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. LncRNAs play an essential role in the complex process of heart formation, and their abnormalities have been associated with several CVDs. This Review article looks at the roles and relationships of long non-coding RNAs (lncRNAs) in a wide range of CVDs, such as heart failure, myocardial infarction, atherosclerosis, and cardiac hypertrophy. In addition, the review delves into the possible uses of lncRNAs in diagnostics, prognosis, and clinical treatments of cardiovascular diseases. Additionally, it considers the field's future prospects while examining how lncRNAs might be altered and its clinical applications. © 2024 Elsevier Inc. All rights reserved.
AB - Long non-coding RNAs (lncRNAs) are RNA molecules that regulate gene expression at several levels, including transcriptional, post-transcriptional, and translational. They have a length of more than 200 nucleotides and cannot code. Many human diseases have been linked to aberrant lncRNA expression, highlighting the need for a better knowledge of disease etiology to drive improvements in diagnostic, prognostic, and therapeutic methods. Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. LncRNAs play an essential role in the complex process of heart formation, and their abnormalities have been associated with several CVDs. This Review article looks at the roles and relationships of long non-coding RNAs (lncRNAs) in a wide range of CVDs, such as heart failure, myocardial infarction, atherosclerosis, and cardiac hypertrophy. In addition, the review delves into the possible uses of lncRNAs in diagnostics, prognosis, and clinical treatments of cardiovascular diseases. Additionally, it considers the field's future prospects while examining how lncRNAs might be altered and its clinical applications. © 2024 Elsevier Inc. All rights reserved.
KW - Myocardial infarction
KW - Heart development
KW - Long non-coding RNA
KW - Myocardial hypertrophy
UR - http://www.scopus.com/inward/record.url?scp=85184522349&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85184522349&origin=recordpage
U2 - 10.1016/j.cpcardiol.2024.102390
DO - 10.1016/j.cpcardiol.2024.102390
M3 - RGC 21 - Publication in refereed journal
SN - 0146-2806
VL - 49
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 3
M1 - 102390
ER -
