Bessel-beam Grueneisen relaxation photoacoustic microscopy with extended depth of field

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Article number116002
Journal / PublicationJournal of Biomedical Optics
Volume20
Issue number11
Online published2 Nov 2015
Publication statusPublished - Nov 2015

Abstract

The short focal depth of a Gaussian beam limits the volumetric imaging speed of optical resolution photoacoustic microscopy (OR-PAM). A Bessel beam, which is diffraction free, provides a long focal depth, but its side lobes deteriorate image quality when the Bessel beam is directly employed to excite photoacoustic (PA) signals in OR-PAM. We present a nonlinear approach based on the Grueneisen relaxation effect to suppress the side-lobe artifacts in PA imaging. This method extends the focal depth of OR-PAM and speeds up volumetric imaging. We experimentally demonstrated a 1-mm focal depth with a 7-μm lateral resolution and volumetrically imaged a carbon fiber and red blood cell samples.

Research Area(s)

  • Bessel beam, Grueneisen relaxation, nonlinear microscopy, photoacoustic

Citation Format(s)

Bessel-beam Grueneisen relaxation photoacoustic microscopy with extended depth of field. / Shi, Junhui; Wang, Lidai; Noordam, Cedric et al.
In: Journal of Biomedical Optics, Vol. 20, No. 11, 116002, 11.2015.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review