Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles

Xiaobing Yang; Yang Wang; Fangzhong Hu; Xiaoli Kan; Chiming Yang; Jiahui Liu; Pei Liu; Qichun Zhang

doi:10.1039/c6ra14897b

Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles

Xiaobing Yang, Yang Wang, Fangzhong Hu^*, Xiaoli Kan, Chiming Yang, Jiahui Liu, Pei Liu, Qichun Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

22 Citations (Scopus)

Abstract

An efficient, mild, metal-free, base-mediated intramolecular cyclization of N-alkyl, N-propargylic β-enaminones has been realized for the generation of polysubstituted pyrrole derivatives. This synthetic transformation tolerates a range of substituted N-alkyl, N-propargylic β-enaminones in moderate to good yields.

Original language	English
Pages (from-to)	68454-68459
Journal	RSC Advances
Volume	6
Issue number	72
Online published	14 Jul 2016
DOIs	https://doi.org/10.1039/c6ra14897b
Publication status	Published - 2016
Externally published	Yes

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title = "Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles",

abstract = "An efficient, mild, metal-free, base-mediated intramolecular cyclization of N-alkyl, N-propargylic β-enaminones has been realized for the generation of polysubstituted pyrrole derivatives. This synthetic transformation tolerates a range of substituted N-alkyl, N-propargylic β-enaminones in moderate to good yields.",

author = "Xiaobing Yang and Yang Wang and Fangzhong Hu and Xiaoli Kan and Chiming Yang and Jiahui Liu and Pei Liu and Qichun Zhang",

year = "2016",

doi = "10.1039/c6ra14897b",

language = "English",

volume = "6",

pages = "68454--68459",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles

AU - Yang, Xiaobing

AU - Wang, Yang

AU - Hu, Fangzhong

AU - Kan, Xiaoli

AU - Yang, Chiming

AU - Liu, Jiahui

AU - Liu, Pei

AU - Zhang, Qichun

PY - 2016

Y1 - 2016

N2 - An efficient, mild, metal-free, base-mediated intramolecular cyclization of N-alkyl, N-propargylic β-enaminones has been realized for the generation of polysubstituted pyrrole derivatives. This synthetic transformation tolerates a range of substituted N-alkyl, N-propargylic β-enaminones in moderate to good yields.

AB - An efficient, mild, metal-free, base-mediated intramolecular cyclization of N-alkyl, N-propargylic β-enaminones has been realized for the generation of polysubstituted pyrrole derivatives. This synthetic transformation tolerates a range of substituted N-alkyl, N-propargylic β-enaminones in moderate to good yields.

UR - http://www.scopus.com/inward/record.url?scp=84979601504&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84979601504&origin=recordpage

U2 - 10.1039/c6ra14897b

DO - 10.1039/c6ra14897b

M3 - RGC 21 - Publication in refereed journal

SN - 2046-2069

VL - 6

SP - 68454

EP - 68459

JO - RSC Advances

JF - RSC Advances

IS - 72

ER -

Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles

Abstract

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