TY - JOUR
T1 - Balancing the Osteogenic and Antibacterial Properties of Titanium by Codoping of Mg and Ag
T2 - An in Vitro and in Vivo Study
AU - Zhao, Yaochao
AU - Cao, Huiliang
AU - Qin, Hui
AU - Cheng, Tao
AU - Qian, Shi
AU - Cheng, Mengqi
AU - Peng, Xiaochun
AU - Wang, Jiaxin
AU - Zhang, Yin
AU - Jin, Guodong
AU - Zhang, Xianlong
AU - Liu, Xuanyong
AU - Chu, Paul K
PY - 2015/8/19
Y1 - 2015/8/19
N2 - To simultaneously enhance the osteogenic and antibacterial properties of titanium, we introduced magnesium (Mg), silver (Ag), or both by using the plasma immersion ion implantation (PIII) technique, producing three PIII sample groups, namely, Mg-doped titanium (Mg-PIII), Ag-doped titanium (Ag-PIII), and Mg and Ag codoped titanium (Mg/Ag-PIII). The in vitro antibacterial efficacy of Mg/Ag-PIII group was about 7-10% higher than that of Ag-PIII. In vitro and in vivo results demonstrated that osteogenic property of Mg/Ag PIII group was better than that of Ag-PIII or Mg-PIII. It was believed that the galvanic effects between Mg and Ag NPs played a key role in facilitating the release of Mg but reducing the release of silver, answering for the selective performances of the Mg/Ag-PIII group over bacterial and mammalian cells. This study demonstrated that the integration of multiple functional elements could be realized by the dual-source PIII technique, and in this case, the antibacterial properties and osteogenic property of titanium could be balanced. (Figure Presented).
AB - To simultaneously enhance the osteogenic and antibacterial properties of titanium, we introduced magnesium (Mg), silver (Ag), or both by using the plasma immersion ion implantation (PIII) technique, producing three PIII sample groups, namely, Mg-doped titanium (Mg-PIII), Ag-doped titanium (Ag-PIII), and Mg and Ag codoped titanium (Mg/Ag-PIII). The in vitro antibacterial efficacy of Mg/Ag-PIII group was about 7-10% higher than that of Ag-PIII. In vitro and in vivo results demonstrated that osteogenic property of Mg/Ag PIII group was better than that of Ag-PIII or Mg-PIII. It was believed that the galvanic effects between Mg and Ag NPs played a key role in facilitating the release of Mg but reducing the release of silver, answering for the selective performances of the Mg/Ag-PIII group over bacterial and mammalian cells. This study demonstrated that the integration of multiple functional elements could be realized by the dual-source PIII technique, and in this case, the antibacterial properties and osteogenic property of titanium could be balanced. (Figure Presented).
KW - antibacteria
KW - magnesium
KW - osteogenesis
KW - plasma immersion ion implantation
KW - silver nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84939833257&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84939833257&origin=recordpage
U2 - 10.1021/acsami.5b04168
DO - 10.1021/acsami.5b04168
M3 - RGC 21 - Publication in refereed journal
SN - 1944-8244
VL - 7
SP - 17826
EP - 17836
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 32
ER -