Bacterial Targeted AIE Photosensitizers Synergistically Promote Chemotherapy for the Treatment of Inflammatory Cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Tianfu Zhang
  • Yang Sylvia Liu
  • Song Lin Chua
  • Ben Zhong Tang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number137579
Journal / PublicationChemical Engineering Journal
Volume447
Online published15 Jun 2022
Publication statusOnline published - 15 Jun 2022

Abstract

Tumor-associated components, especially extratumoral bacteria (EB) in the form of biofilms, could exacerbate cancer progression and hinder the effectiveness of antitumor drugs by covering the interstitial tumor space. Although photodynamic therapy (PDT) is a promising modality to kill cancer cells and bacteria with high spatiotemporal precision, the low penetration of light limits its potential in deep tumor therapy. Furthermore, current 2D culture-based preclinical in vitro models failed to reflect the complexity of the tumor microenvironment. Here, we developed an unprecedented “1 + 1 > 2′′ combinatorial strategy of PDT and chemotherapy by co-delivering a bacterial-targeted photosensitizer with aggregation-induced emission (AIE) property and an anticancer drug, doxorubicin. The theranostic system could selectively visualize and rapidly kill EB, using a microfluidic-based 3D bladder cancer model. The effect of combinatorial therapy was synergistic, resulting in improved efficacy, as evidenced by at least a 2.5-fold reduction in the half-maximal inhibitory concentration of doxorubicin. Validation using a fish wound infection model further demonstrated the feasibility of AIE photosensitizers for efficient fluorescence imaging-guided PDT in vivo. Overall, we proposed a robust AIE PDT/ chemotherapy strategy that shows great potential for rapid and concurrent treatment of bacterially infected cancer patients.

Research Area(s)

  • Aggregation-induced emission, Photodynamic therapy, Synergistic therapy, Microfluidics, Inflammatory cancer

Citation Format(s)

Bacterial Targeted AIE Photosensitizers Synergistically Promote Chemotherapy for the Treatment of Inflammatory Cancer. / Zhang, Tianfu ; Deng, Yanlin; Liu, Yang Sylvia; Chua, Song Lin; Tang, Ben Zhong; Khoo, Bee Luan.

In: Chemical Engineering Journal, Vol. 447, 137579, 01.11.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review