Bacterial physiology is a key modulator of the antibacterial activity of graphene oxide

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • H. Enis Karahan
  • Li Wei
  • Kunli Goh
  • Zhe Liu
  • Özgür Birer
  • Fariba Dehghani
  • Jun Wei
  • Yuan Chen

Detail(s)

Original languageEnglish
Pages (from-to)17181-17189
Journal / PublicationNanoscale
Volume8
Issue number39
Online published12 Aug 2016
Publication statusPublished - 21 Oct 2016
Externally publishedYes

Abstract

Carbon-based nanomaterials have a great potential as novel antibacterial agents; however, their interactions with bacteria are not fully understood. This study demonstrates that the antibacterial activity of graphene oxide (GO) depends on the physiological state of cells for both Gram-negative and -positive bacteria. GO susceptibility of bacteria is the highest in the exponential growth phase, which are in growing physiology, and stationary-phase (non-growing) cells are quite resistant against GO. Importantly, the order of GO susceptibility of E. coli with respect to the growth phases (exponential ≫ decline > stationary) correlates well with the changes in the envelope ultrastructures of the cells. Our findings are not only fundamentally important but also particularly critical for practical antimicrobial applications of carbon-based nanomaterials.

Citation Format(s)

Bacterial physiology is a key modulator of the antibacterial activity of graphene oxide. / Karahan, H. Enis; Wei, Li; Goh, Kunli; Liu, Zhe; Birer, Özgür; Dehghani, Fariba; Xu, Chenjie; Wei, Jun; Chen, Yuan.

In: Nanoscale, Vol. 8, No. 39, 21.10.2016, p. 17181-17189.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review