Axonal Fiber Terminations Concentrate on Gyri

Jingxin Nie; Lei Guo; Kaiming Li; Yonghua Wang; Guojun Chen; Longchuan Li; Hanbo Chen; Fan Deng; Xi Jiang; Tuo Zhang; Ling Huang; Carlos Faraco; Degang Zhang; Cong Guo; Pew Thian Yap; Xintao Hu; Gang Li; Jinglei Lv; Yixuan Yuan; Dajiang Zhu; Junwei Han; Dean Sabatinelli; Qun Zhao; L. Stephen Miller; Bingqian Xu; Ping Shen; Simon Platt; Dinggang Shen; Xiaoping Hu; Tianming Liu

doi:10.1093/cercor/bhr361

Axonal Fiber Terminations Concentrate on Gyri

Jingxin Nie, Lei Guo, Kaiming Li, Yonghua Wang, Guojun Chen, Longchuan Li, Hanbo Chen, Fan Deng, Xi Jiang, Tuo Zhang, Ling Huang, Carlos Faraco, Degang Zhang, Cong Guo, Pew Thian Yap, Xintao Hu, Gang Li, Jinglei Lv, Yixuan Yuan, Dajiang ZhuJunwei Han, Dean Sabatinelli, Qun Zhao, L. Stephen Miller, Bingqian Xu, Ping Shen, Simon Platt, Dinggang Shen, Xiaoping Hu, Tianming Liu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

117 Citations (Scopus)

Abstract

Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

Original language	English
Pages (from-to)	2831-2839
Journal	Cerebral Cortex
Volume	22
Issue number	12
Online published	20 Dec 2011
DOIs	https://doi.org/10.1093/cercor/bhr361
Publication status	Published - Dec 2012
Externally published	Yes

Funding

Northwestern Polytechnic University Foundation for Fundamental Research to J. Nie, L. Guo, and G. Li; National Institutes of Health (K01 EB 006878 and R01 HL087923-03S2 to T. Liu, PO1 AG026423 to L. Li and X. Hu); The University of Georgia start-up research funding to T. Liu; China Government Scholarship to K. Li, T. Zhang, and D. Zhang.

Research Keywords

cortical folding
diffusion tensor imaging
shape analysis

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10.1093/cercor/bhr361

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title = "Axonal Fiber Terminations Concentrate on Gyri",

abstract = "Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.",

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author = "Jingxin Nie and Lei Guo and Kaiming Li and Yonghua Wang and Guojun Chen and Longchuan Li and Hanbo Chen and Fan Deng and Xi Jiang and Tuo Zhang and Ling Huang and Carlos Faraco and Degang Zhang and Cong Guo and Yap, {Pew Thian} and Xintao Hu and Gang Li and Jinglei Lv and Yixuan Yuan and Dajiang Zhu and Junwei Han and Dean Sabatinelli and Qun Zhao and Miller, {L. Stephen} and Bingqian Xu and Ping Shen and Simon Platt and Dinggang Shen and Xiaoping Hu and Tianming Liu",

year = "2012",

month = dec,

doi = "10.1093/cercor/bhr361",

language = "English",

volume = "22",

pages = "2831--2839",

journal = "Cerebral Cortex",

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publisher = "Oxford University Press",

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Nie, J, Guo, L, Li, K, Wang, Y, Chen, G, Li, L, Chen, H, Deng, F, Jiang, X, Zhang, T, Huang, L, Faraco, C, Zhang, D, Guo, C, Yap, PT, Hu, X, Li, G, Lv, J, Yuan, Y, Zhu, D, Han, J, Sabatinelli, D, Zhao, Q, Miller, LS, Xu, B, Shen, P, Platt, S, Shen, D, Hu, X & Liu, T 2012, 'Axonal Fiber Terminations Concentrate on Gyri', Cerebral Cortex, vol. 22, no. 12, pp. 2831-2839. https://doi.org/10.1093/cercor/bhr361

TY - JOUR

T1 - Axonal Fiber Terminations Concentrate on Gyri

AU - Nie, Jingxin

AU - Guo, Lei

AU - Li, Kaiming

AU - Wang, Yonghua

AU - Chen, Guojun

AU - Li, Longchuan

AU - Chen, Hanbo

AU - Deng, Fan

AU - Jiang, Xi

AU - Zhang, Tuo

AU - Huang, Ling

AU - Faraco, Carlos

AU - Zhang, Degang

AU - Guo, Cong

AU - Yap, Pew Thian

AU - Hu, Xintao

AU - Li, Gang

AU - Lv, Jinglei

AU - Yuan, Yixuan

AU - Zhu, Dajiang

AU - Han, Junwei

AU - Sabatinelli, Dean

AU - Zhao, Qun

AU - Miller, L. Stephen

AU - Xu, Bingqian

AU - Shen, Ping

AU - Platt, Simon

AU - Shen, Dinggang

AU - Hu, Xiaoping

AU - Liu, Tianming

PY - 2012/12

Y1 - 2012/12

N2 - Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

AB - Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

KW - cortical folding

KW - diffusion tensor imaging

KW - shape analysis

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U2 - 10.1093/cercor/bhr361

DO - 10.1093/cercor/bhr361

M3 - RGC 21 - Publication in refereed journal

C2 - 22190432

AN - SCOPUS:84869015890

SN - 1047-3211

VL - 22

SP - 2831

EP - 2839

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 12

ER -

Axonal Fiber Terminations Concentrate on Gyri

Abstract

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