Axonal Fiber Terminations Concentrate on Gyri

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jingxin Nie
  • Lei Guo
  • Kaiming Li
  • Yonghua Wang
  • Guojun Chen
  • Longchuan Li
  • Hanbo Chen
  • Fan Deng
  • Xi Jiang
  • Tuo Zhang
  • Ling Huang
  • Carlos Faraco
  • Degang Zhang
  • Cong Guo
  • Pew Thian Yap
  • Xintao Hu
  • Gang Li
  • Jinglei Lv
  • Dajiang Zhu
  • Junwei Han
  • Dean Sabatinelli
  • Qun Zhao
  • L. Stephen Miller
  • Bingqian Xu
  • Ping Shen
  • Simon Platt
  • Dinggang Shen
  • Xiaoping Hu
  • Tianming Liu

Detail(s)

Original languageEnglish
Pages (from-to)2831-2839
Journal / PublicationCerebral Cortex
Volume22
Issue number12
Online published20 Dec 2011
Publication statusPublished - Dec 2012
Externally publishedYes

Abstract

Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

Research Area(s)

  • cortical folding, diffusion tensor imaging, shape analysis

Citation Format(s)

Axonal Fiber Terminations Concentrate on Gyri. / Nie, Jingxin; Guo, Lei; Li, Kaiming et al.

In: Cerebral Cortex, Vol. 22, No. 12, 12.2012, p. 2831-2839.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review