Skip to main navigation Skip to search Skip to main content

Awarding additional MELD points to the shortest waitlist candidates improves sex disparity in access to liver transplant in the United States

Sarah Bernards, Eric Lee, Ngai Leung, Mustafa Akan, Kyra Gan, Huan Zhao, Monika Sarkar, Sridhar Tayur, Neil Mehta*

*Corresponding author for this work

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    112 Downloads (CityUHK Scholars)

    Abstract

    Since the introduction of the MELD-based allocation system, women are now 30% less likely than men to undergo liver transplant (LT) and have 20% higher waitlist mortality. These disparities are in large part due to height differences in men and women though no national policies have been implemented to reduce sex disparities. Patients were identified using the Scientific Registry of Transplant Recipients (SRTR) from 2014 to 2019. Patients were categorized into five groups by first dividing into thirds by height then dividing the shortest third into three groups to capture more granular differences in the most disadvantaged patients (<166 cm). We then used LSAM to model waitlist outcomes in five versions of awarding additional MELD points to shorter candidates compared to current policy. We identified two proposed policy changes LSAM scenarios that resulted in improvement in LT and death percentage for the shortest candidates with the least negative impact on taller candidates. In conclusion, awarding an additional 1–2 MELD points to the shortest 8% of LT candidates would improve waitlist outcomes for women. This strategy should be considered in national policy allocation to address sex-based disparities in LT.
    Original languageEnglish
    Pages (from-to)2912-2920
    JournalAmerican Journal of Transplantation
    Volume22
    Issue number12
    Online published24 Jul 2022
    DOIs
    Publication statusPublished - Dec 2022

    Bibliographical note

    Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

    Research Keywords

    • cirrhosis
    • classification systems: Model for Endstage Liver Disease (MELD)
    • clinical research/practice
    • gender
    • health services and outcomes research
    • liver transplantation/hepatology
    • organ allocation
    • United Network for Organ Sharing (UNOS)

    Publisher's Copyright Statement

    • COPYRIGHT TERMS OF DEPOSITED FINAL PUBLISHED VERSION FILE: © 2022 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. This full text is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.

    Fingerprint

    Dive into the research topics of 'Awarding additional MELD points to the shortest waitlist candidates improves sex disparity in access to liver transplant in the United States'. Together they form a unique fingerprint.

    Cite this