Automatic Sample Alignment under Microscopy for 360° Imaging Based on the Nanorobotic Manipulation System

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Original languageEnglish
Article number7762898
Pages (from-to)220-226
Journal / PublicationIEEE Transactions on Robotics
Issue number1
Online published1 Dec 2016
Publication statusPublished - Feb 2017


Microscopy has been an indispensable tool for micro/nanosample imaging, manipulation, and characterization. However, viewing the micro/nanosample from multidirection is still a big challenge for current microscopy. To address the above issue, this paper proposes a novel nanorobotic manipulation system for the automatic alignment and multidirectional imaging under microscopes. First, a miniature rotation robot with three degrees of freedom is designed and integrated with a microscope. Then, a forward-backward alignment strategy containing three loops, i.e., position shift loop, angle loop, and magnification loop, is proposed to align the sample to the rotation axis of the robot automatically. After that, the sample is imaged from multidirection by rotating the robot with one revolution (360°). Finally, the alignment accuracy is evaluated and multi-directional images of various samples are implemented. This study provides a new way for the microscopic imaging, which is expected to exert a significant impact in multiple fields on a small scale, including microscopy imaging, microdefect detection, micromanipulation, in situ characterization, and so on.

Research Area(s)

  • Microscopy multidirectional imaging, nanoautomation, nanomanipulation, nanorobotic manipulation system, rotation alignment