Automated detection framework of the calcified plaque with acoustic shadowing in IVUS images

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

15 Scopus Citations
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Author(s)

  • Zhifan Gao
  • Wei Guo
  • Xin Liu
  • Wenhua Huang
  • Heye Zhang
  • Ning Tan
  • William Kongto Hau
  • Huafeng Liu

Detail(s)

Original languageEnglish
Article numbere109997
Journal / PublicationPLoS ONE
Volume9
Issue number11
Online published5 Nov 2014
Publication statusOnline published - 5 Nov 2014
Externally publishedYes

Abstract

Intravascular Ultrasound (IVUS) is one ultrasonic imaging technology to acquire vascular cross-sectional images for the visualization of the inner vessel structure. This technique has been widely used for the diagnosis and treatment of coronary artery diseases. The detection of the calcified plaque with acoustic shadowing in IVUS images plays a vital role in the quantitative analysis of atheromatous plaques. The conventional method of the calcium detection is manual drawing by the doctors. However, it is very time-consuming, and with high inter-observer and intra-observer variability between different doctors. Therefore, the computer-aided detection of the calcified plaque is highly desired. In this paper, an automated method is proposed to detect the calcified plaque with acoustic shadowing in IVUS images by the Rayleigh mixture model, the Markov random field, the graph searching method and the prior knowledge about the calcified plaque. The performance of our method was evaluated over 996 in-vivo IVUS images acquired from eight patients, and the detected calcified plaques are compared with manually detected calcified plaques by one cardiology doctor. The experimental results are quantitatively analyzed separately by three evaluation methods, the test of the sensitivity and specificity, the linear regression and the Bland-Altman analysis. The first method is used to evaluate the ability to distinguish between IVUS images with and without the calcified plaque, and the latter two methods can respectively measure the correlation and the agreement between our results and manual drawing results for locating the calcified plaque in the IVUS image. High sensitivity (94.68%) and specificity (95.82%), good correlation and agreement (>96.82% results fall within the 95% confidence interval in the Student t-test) demonstrate the effectiveness of the proposed method in the detection of the calcified plaque with acoustic shadowing in IVUS images.

Citation Format(s)

Automated detection framework of the calcified plaque with acoustic shadowing in IVUS images. / Gao, Zhifan; Guo, Wei; Liu, Xin; Huang, Wenhua; Zhang, Heye; Tan, Ning; Hau, William Kongto; Zhang, Yuan-Ting; Liu, Huafeng.

In: PLoS ONE, Vol. 9, No. 11, e109997, 05.11.2014.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal