ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Original language | English |
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Article number | 4978 |
Journal / Publication | Nature Communications |
Volume | 14 |
Online published | 17 Aug 2023 |
Publication status | Published - 2023 |
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85168276645&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(c81d2c69-e989-4476-908e-f384a0512d72).html |
Abstract
Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly understood how SCs enter cell cycle to become activated upon injury. Here we report that AP-1 family member ATF3 (Activating Transcription Factor 3) prevents SC premature activation. Atƒ3 is rapidly and transiently induced in SCs upon activation. Short-term deletion of Atƒ3 in SCs accelerates acute injury-induced regeneration, however, its long-term deletion exhausts the SC pool and thus impairs muscle regeneration. The Atf3 loss also provokes SC activation during voluntary exercise and enhances the activation during endurance exercise. Mechanistically, ATF3 directly activates the transcription of Histone 2B genes, whose reduction accelerates nucleosome displacement and gene transcription required for SC activation. Finally, the ATF3-dependent H2B expression also prevents genome instability and replicative senescence in SCs. Therefore, this study has revealed a previously unknown mechanism for preserving the SC population by actively suppressing precocious activation, in which ATF3 is a key regulator. © 2023, Springer Nature Limited.
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ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression. / Zhang, Suyang; Yang, Feng; Huang, Yile et al.
In: Nature Communications, Vol. 14, 4978, 2023.
In: Nature Communications, Vol. 14, 4978, 2023.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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