Asymmetrical Titanium Oxide Patterns For Unidirectional Cell Guidance

Yijun Cheng; Stella W. Pang

Asymmetrical Titanium Oxide Patterns For Unidirectional Cell Guidance

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

Controlling the direction of cell migration is crucial for wound healing and tissue regeneration. To this end, polydimethylsiloxane (PDMS) platforms with a thin titanium oxide (TiO_x with x=1.4) layer patterned in grating and arrowhead shapes were fabricated. In a novel approach, MC3T3-E1 cells seeded onto the platforms were confined to migrate over the patterned TiO_x layer without physical barriers, instead of on the PDMS surface itself. Cells on a grating-shaped pattern were found to align with the grating orientation, exhibiting bidirectional migration. In comparison, the asymmetrical arrowheads of a patterned TiO_x layer were able to guide cells along the tips of the arrowheads, which had larger contact areas. These findings suggest that biointerfaces with ultrathin patterns, such as the ones tested here, could offer better guidance over cell migration and inspire the development of new designs for biointerfaces. © 2023 IEEJ.

Original language	English
Title of host publication	2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)
Publisher	IEEE
Pages	919-922
ISBN (Electronic)	978-4-88686-435-2
ISBN (Print)	979-8-3503-3302-2
Publication status	Published - Jun 2023
Event	22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023) - Kyoto International Conference Center, Kyoto, Japan Duration: 25 Jun 2023 → 29 Jun 2023 https://transducers2023.org/

Publication series

Name	International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers
ISSN (Print)	2167-0013
ISSN (Electronic)	2167-0021

Conference

Conference	22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023)
Abbreviated title	Transducers2023
Place	Japan
City	Kyoto
Period	25/06/23 → 29/06/23
Internet address	https://transducers2023.org/

Research Keywords

Unidirectional Cell Migration
Patterned Titanium Oxide
Arrowhead Pattern
Grating
MC3T3-E1 Cell

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Cite this

@inproceedings{7c634911172c46e2aabba84b8cc75d3f,

title = "Asymmetrical Titanium Oxide Patterns For Unidirectional Cell Guidance",

abstract = "Controlling the direction of cell migration is crucial for wound healing and tissue regeneration. To this end, polydimethylsiloxane (PDMS) platforms with a thin titanium oxide (TiOx with x=1.4) layer patterned in grating and arrowhead shapes were fabricated. In a novel approach, MC3T3-E1 cells seeded onto the platforms were confined to migrate over the patterned TiOx layer without physical barriers, instead of on the PDMS surface itself. Cells on a grating-shaped pattern were found to align with the grating orientation, exhibiting bidirectional migration. In comparison, the asymmetrical arrowheads of a patterned TiOx layer were able to guide cells along the tips of the arrowheads, which had larger contact areas. These findings suggest that biointerfaces with ultrathin patterns, such as the ones tested here, could offer better guidance over cell migration and inspire the development of new designs for biointerfaces. {\textcopyright} 2023 IEEJ.",

keywords = "Unidirectional Cell Migration, Patterned Titanium Oxide, Arrowhead Pattern, Grating, MC3T3-E1 Cell",

author = "Yijun Cheng and Pang, {Stella W.}",

year = "2023",

month = jun,

language = "English",

isbn = "979-8-3503-3302-2",

series = "International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers",

publisher = "IEEE",

pages = "919--922",

booktitle = "2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)",

address = "United States",

note = "22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023), Transducers2023 ; Conference date: 25-06-2023 Through 29-06-2023",

url = "https://transducers2023.org/",

}

Cheng, Y & Pang, SW 2023, Asymmetrical Titanium Oxide Patterns For Unidirectional Cell Guidance. in 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers, IEEE, pp. 919-922, 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023), Kyoto, Japan, 25/06/23. <https://ieeexplore.ieee.org/document/10516950>

Asymmetrical Titanium Oxide Patterns For Unidirectional Cell Guidance. / Cheng, Yijun ; Pang, Stella W.
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). IEEE, 2023. p. 919-922 (International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Asymmetrical Titanium Oxide Patterns For Unidirectional Cell Guidance

AU - Cheng, Yijun

AU - Pang, Stella W.

PY - 2023/6

Y1 - 2023/6

N2 - Controlling the direction of cell migration is crucial for wound healing and tissue regeneration. To this end, polydimethylsiloxane (PDMS) platforms with a thin titanium oxide (TiOx with x=1.4) layer patterned in grating and arrowhead shapes were fabricated. In a novel approach, MC3T3-E1 cells seeded onto the platforms were confined to migrate over the patterned TiOx layer without physical barriers, instead of on the PDMS surface itself. Cells on a grating-shaped pattern were found to align with the grating orientation, exhibiting bidirectional migration. In comparison, the asymmetrical arrowheads of a patterned TiOx layer were able to guide cells along the tips of the arrowheads, which had larger contact areas. These findings suggest that biointerfaces with ultrathin patterns, such as the ones tested here, could offer better guidance over cell migration and inspire the development of new designs for biointerfaces. © 2023 IEEJ.

AB - Controlling the direction of cell migration is crucial for wound healing and tissue regeneration. To this end, polydimethylsiloxane (PDMS) platforms with a thin titanium oxide (TiOx with x=1.4) layer patterned in grating and arrowhead shapes were fabricated. In a novel approach, MC3T3-E1 cells seeded onto the platforms were confined to migrate over the patterned TiOx layer without physical barriers, instead of on the PDMS surface itself. Cells on a grating-shaped pattern were found to align with the grating orientation, exhibiting bidirectional migration. In comparison, the asymmetrical arrowheads of a patterned TiOx layer were able to guide cells along the tips of the arrowheads, which had larger contact areas. These findings suggest that biointerfaces with ultrathin patterns, such as the ones tested here, could offer better guidance over cell migration and inspire the development of new designs for biointerfaces. © 2023 IEEJ.

KW - Unidirectional Cell Migration

KW - Patterned Titanium Oxide

KW - Arrowhead Pattern

KW - Grating

KW - MC3T3-E1 Cell

UR - http://www.scopus.com/inward/record.url?scp=85193495410&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85193495410&origin=recordpage

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 979-8-3503-3302-2

T3 - International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers

SP - 919

EP - 922

BT - 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)

PB - IEEE

T2 - 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023)

Y2 - 25 June 2023 through 29 June 2023

ER -

Asymmetrical Titanium Oxide Patterns For Unidirectional Cell Guidance

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