Asymmetric Conjugate Addition of Organoboron Reagents to Common Enones Using Copper Catalysts

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Chunlin Wu
  • Guizhou Yue
  • Christian Duc-Trieu Nielsen
  • Kai Xu
  • Jianrong Zhou

Detail(s)

Original languageEnglish
Pages (from-to)742-745
Journal / PublicationJournal of the American Chemical Society
Volume138
Issue number3
Publication statusPublished - 27 Jan 2016
Externally publishedYes

Abstract

Copper complexes of phosphoramidites efficiently catalyzed asymmetric addition of arylboron reagents to acyclic enones. Importantly, rare 1,4-insertion of arylcopper(I) was identified which led directly to O-bound copper enolates. The new mechanism is fundamentally different from classical oxidative addition/reductive elimination of organocopper(I) on enones.

Citation Format(s)

Asymmetric Conjugate Addition of Organoboron Reagents to Common Enones Using Copper Catalysts. / Wu, Chunlin; Yue, Guizhou; Nielsen, Christian Duc-Trieu et al.

In: Journal of the American Chemical Society, Vol. 138, No. 3, 27.01.2016, p. 742-745.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review