Association of concurrent porcine circovirus (PCV) 2a and 2b infection with PCV associated disease in vaccinated pigs

Priscilla F. Gerber; John Johnson; Huigang Shen; Dave Striegel; Chao-Ting Xiao; Patrick G. Halbur; Tanja Opriessnig

doi:10.1016/j.rvsc.2013.06.004

Association of concurrent porcine circovirus (PCV) 2a and 2b infection with PCV associated disease in vaccinated pigs

Priscilla F. Gerber, John Johnson, Huigang Shen, Dave Striegel, Chao-Ting Xiao, Patrick G. Halbur, Tanja Opriessnig

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

22 Citations (Scopus)

Abstract

Investigations were performed to characterize porcine circovirus (PCV) 2 infection in 10. week old pigs from a case of apparent vaccine failure. Thirty serum samples were collected from affected or non-affected pigs and tested for anti-PCV2 antibodies and PCV2 DNA. To address potential PCV2 vaccine compliance issues, samples were tested for antibodies against baculovirus and Mycoplasma hyopneumoniae antigens present in the PCV2 vaccine utilized in this herd. Both PCV2a and PCV2b DNA were detected in 76.6% (90% positive for PCV2a, 86.6% positive for PCV2b), anti-PCV2 IgG in 90%, anti-baculovirus IgG in 50%, and anti- M. hyopneumoniae IgG in 43.3% of the samples. Frequency of baculovirus and M. hyopneumoniae seropositive pigs was significantly lower in affected pigs. The finding that only 50% of the pigs developed a detectable immune response to vaccination suggests poor vaccine compliance or efficacy. Concurrent PCV2a and PCV2b infection was common and may have resulted in enhanced PCV2 replication. © 2013 Elsevier Ltd.

Original language	English
Pages (from-to)	775-781
Journal	Research in Veterinary Science
Volume	95
Issue number	2
DOIs	https://doi.org/10.1016/j.rvsc.2013.06.004
Publication status	Published - Oct 2013
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected]

Research Keywords

Co-infection
Porcine circovirus 2
Porcine circovirus associated disease

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title = "Association of concurrent porcine circovirus (PCV) 2a and 2b infection with PCV associated disease in vaccinated pigs",

abstract = "Investigations were performed to characterize porcine circovirus (PCV) 2 infection in 10. week old pigs from a case of apparent vaccine failure. Thirty serum samples were collected from affected or non-affected pigs and tested for anti-PCV2 antibodies and PCV2 DNA. To address potential PCV2 vaccine compliance issues, samples were tested for antibodies against baculovirus and Mycoplasma hyopneumoniae antigens present in the PCV2 vaccine utilized in this herd. Both PCV2a and PCV2b DNA were detected in 76.6% (90% positive for PCV2a, 86.6% positive for PCV2b), anti-PCV2 IgG in 90%, anti-baculovirus IgG in 50%, and anti- M. hyopneumoniae IgG in 43.3% of the samples. Frequency of baculovirus and M. hyopneumoniae seropositive pigs was significantly lower in affected pigs. The finding that only 50% of the pigs developed a detectable immune response to vaccination suggests poor vaccine compliance or efficacy. Concurrent PCV2a and PCV2b infection was common and may have resulted in enhanced PCV2 replication. {\textcopyright} 2013 Elsevier Ltd.",

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AU - Shen, Huigang

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AU - Xiao, Chao-Ting

AU - Halbur, Patrick G.

AU - Opriessnig, Tanja

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KW - Porcine circovirus associated disease

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Association of concurrent porcine circovirus (PCV) 2a and 2b infection with PCV associated disease in vaccinated pigs

Abstract

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