Assessment of the Immune Response of Clinically Infected Calves to Cryptosporidium parvum Infection

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Wael El-Deeb
  • Olimpia Iacob
  • Mahmoud Fayez
  • Abdulrahman Alhaider
  • Hermine V. Mkrtchyan
  • Abdelazim Ibrahim
  • Naser Alhumam

Detail(s)

Original languageEnglish
Article number1151
Journal / PublicationAgriculture (Switzerland)
Volume12
Issue number8
Online published4 Aug 2022
Publication statusPublished - Aug 2022

Link(s)

Abstract

Cryptosporidium parvum (C. parvum) infection is one of the main causes of diarrhea in calves. The current study assessed the role of blood biomarkers (acute-phase proteins (APPs), procalcitonin, neopterin, cytokines, and oxidative stress in the pathogenesis, diagnosis, and prognosis of calves naturally infected with C. parvum. Fifty-seven calves, aged from 10 to 45 days, were detected positive for C. parvum and were allotted into the diseased group; twenty healthy calves were selected as a control group. Serum amyloid A, haptoglobin, cytokines, neopterin, procalcitonin, and stress biomarkers were tested in the diseased and healthy groups. The serum levels of APPs, cytokines, neopterin, procalcitonin, and malondialdehyde increased, whereas antioxidant levels were significantly decreased in diseased calves compared to the healthy group. Moreover, all examined biomarkers were significantly altered towards normal values in infected calves following different treatment protocols. All biomarkers examined were highly effective in discriminating between C. parvum-infected calves and healthy individuals. Furthermore, the area under the curve (AUC) showed that all tested parameters had a higher degree of prognostic accuracy in predicting the treatment response of calves naturally infected with C. parvum. Our data suggest the usefulness of the examined biomarkers in the immune pathogenesis of the C. parvum infection in calves, contributing to diagnosis and treatment efficacy.

Research Area(s)

  • procalcitonin, neopterin, cytokines, Cryptosporidium, haptoglobin, malondialdehyde

Citation Format(s)

Assessment of the Immune Response of Clinically Infected Calves to Cryptosporidium parvum Infection. / El-Deeb, Wael; Iacob, Olimpia; Fayez, Mahmoud et al.
In: Agriculture (Switzerland), Vol. 12, No. 8, 1151, 08.2022.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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