Assessing the toxicity of triphenyltin to different life stages of the marine medaka Oryzias melastigma through a series of life-cycle based experiments

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)847-855
Journal / PublicationMarine Pollution Bulletin
Volume124
Issue number2
Online published24 Feb 2017
Publication statusPublished - 30 Nov 2017

Abstract

Toxic effects of triphenyltin (TPT) to different life stages of the marine medaka Oryzias melastigma were investigated through a series of life-cycle based exposure experiments. In embryo stage, TPT exposure could elevate the heartbeat rate at Day 6–8 post-fertilization and increase the expression levels of five heart development related genes (i.e., ATPase, COX2, BMP4, GATA4 and NKX2.5). In larval stage, TPT shortened the body length at ≥ 10 μg/L and suppressed the swimming activity of the fish larvae at Day 1 post-hatching at 50 μg/L. In reproductive stage, TPT exposure resulted in a male-biased sex ratio (2 μg/L) and reduced the gonadosomatic index (GSI) in females (≥ 0.1 μg/L), which might in turn lead to a decline in their population fitness. The reproductive stage of O. melastigma was more sensitive to TPT than other stages, while the GSI of female medaka was the most sensitive endpoint.

Research Area(s)

  • Gonadosomatic index, Growth rate, Heartbeat, Reproduction, Swimming activity

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