Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Article numbere59837
Journal / PublicationJournal of Visualized Experiments
Issue number156
Online published7 Feb 2020
Publication statusPublished - Feb 2020

Abstract

The overall goal of this study is to assess the autonomic and behavioral effects of passive motion in rodents using the elevator vertical motion and Ferris-wheel rotation devices. These assays can help confirm the integrity and normal functioning of the autonomic system. They are coupled to quantitative measures based on defecation counting, open-field examination, and balance beam crossing. The advantages of these assays are their simplicity, reproducibility, and quantitative behavioral measures. The limitations of these assays are that the autonomic reactions could be epiphenomena of non-vestibular disorders and that a functioning vestibular system is required. Examination of disorders such as motion sickness will be greatly aided by the detailed procedures of these assays.

Research Area(s)

  • Behavior, motion sickness, balance beam, ferris-wheel roatation, elevator vertical motion, rodents, open-field examination

Citation Format(s)

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation. / Manno, Francis A. M.; Pan, Leilei; Mao, Yuqi; Su, Yang; Manno, Sinai H. C.; Cheng, Shuk Han; Lau, Condon; Cai, Yiling.

In: Journal of Visualized Experiments, No. 156, e59837, 02.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review