Assessing epithelial cell nuclear morphology by using azimuthal light scattering spectroscopy
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 3119-3121 |
Journal / Publication | Optics Letters |
Volume | 31 |
Issue number | 21 |
Publication status | Published - 1 Nov 2006 |
Externally published | Yes |
Link(s)
Abstract
We describe azimuthal light scattering spectroscopy (φ/LSS), a novel technique for assessing epithelial-cell nuclear morphology. The difference between the spectra measured at azimuthal angles φ=0° and φ=90° preferentially isolates the single backscattering contribution due to large (∼10 μm) structures such as epithelial cell nuclei by discriminating against scattering from smaller organelles and diffusive background. We demonstrate the feasibility of using φ/LSS for cancer detection by showing that spectra from cancerous colon tissue exhibit significantly greater azimuthal asymmetry than spectra from normal colonic tissues. © 2006 Optical Society of America.
Research Area(s)
Citation Format(s)
Assessing epithelial cell nuclear morphology by using azimuthal light scattering spectroscopy. / Yu, Chung-Chieh; Lau, Condon; Tunnell, James W. et al.
In: Optics Letters, Vol. 31, No. 21, 01.11.2006, p. 3119-3121.
In: Optics Letters, Vol. 31, No. 21, 01.11.2006, p. 3119-3121.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review