Artificial Vascular with Pressure-Responsive Property based on Deformable Microfluidic Channels

Zhenlin Chen; Lei Fan; Shuxun Chen; Han Zhao; Qiang Zhang; Yun Qu; Ya Huang; Xinge Yu; Dong Sun

doi:10.1002/adhm.202304532

Artificial Vascular with Pressure-Responsive Property based on Deformable Microfluidic Channels

Zhenlin Chen
, Lei Fan
, Shuxun Chen
, Han Zhao
, Qiang Zhang
, Yun Qu
, Ya Huang
, Xinge Yu^*
, Dong Sun^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

11 Citations (Scopus)

18 Downloads (CityUHK Scholars)

Abstract

In vitro blood vessel models are significant for disease modeling, drug assays, and therapeutic development. Microfluidic technologies allow to create physiologically relevant culture models reproducing the features of the in vivo vascular microenvironment. However, current microfluidic technologies are limited by impractical rectangular cross-sections and single or nonsynchronous compound mechanical stimuli. This study proposes a new strategy for creating round-shaped deformable soft microfluidic channels to serve as artificial in vitro vasculature for developing in vitro models with vascular physio-mechanical microenvironments. Endothelial cells seeded into vascular models are used to assess the effects of a remodeled in vivo mechanical environment. Furthermore, a 3D stenosis model is constructed to recapitulate the flow disturbances in atherosclerosis. Soft microchannels can also be integrated into traditional microfluidics to realize multifunctional composite systems. This technology provides new insights into applying microfluidic chips and a prospective approach for constructing in vitro blood vessel models. © 2024 Wiley-VCH GmbH.

Original language	English
Article number	2304532
Journal	Advanced Healthcare Materials
Volume	13
Issue number	20
Online published	26 Apr 2024
DOIs	https://doi.org/10.1002/adhm.202304532
Publication status	Published - 7 Aug 2024

Funding

The work described in this paper was supported by the InnoHK Project on Project 2.2—AI-based 3D ultrasound imaging algorithm at Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), in part by grants from the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. CityU C1134-20G and CityU 11211421), Shenzhen Science and Technology Project, China (Project No. SGDX20201103093 00502), and National Natural Science Foundation of China (Grants No. 62122002).

Research Keywords

deformable microchannels
environments
mechanical
microfluidics
multiple stimulations
vascular models

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the peer reviewed version of the following article: Chen, Z., Fan, L., Chen, S., Zhao, H., Zhang, Q., Qu, Y., Huang, Y., Yu, X., & Sun, D. (2024). Artificial Vascular with Pressure-Responsive Property based on Deformable Microfluidic Channels. Advanced Healthcare Materials, 13(20), Article 2304532,, which has been published in final form at https://doi.org/10.1002/adhm.202304532.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

RGC Funding Information

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title = "Artificial Vascular with Pressure-Responsive Property based on Deformable Microfluidic Channels",

abstract = "In vitro blood vessel models are significant for disease modeling, drug assays, and therapeutic development. Microfluidic technologies allow to create physiologically relevant culture models reproducing the features of the in vivo vascular microenvironment. However, current microfluidic technologies are limited by impractical rectangular cross-sections and single or nonsynchronous compound mechanical stimuli. This study proposes a new strategy for creating round-shaped deformable soft microfluidic channels to serve as artificial in vitro vasculature for developing in vitro models with vascular physio-mechanical microenvironments. Endothelial cells seeded into vascular models are used to assess the effects of a remodeled in vivo mechanical environment. Furthermore, a 3D stenosis model is constructed to recapitulate the flow disturbances in atherosclerosis. Soft microchannels can also be integrated into traditional microfluidics to realize multifunctional composite systems. This technology provides new insights into applying microfluidic chips and a prospective approach for constructing in vitro blood vessel models. {\textcopyright} 2024 Wiley-VCH GmbH.",

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author = "Zhenlin Chen and Lei Fan and Shuxun Chen and Han Zhao and Qiang Zhang and Yun Qu and Ya Huang and Xinge Yu and Dong Sun",

year = "2024",

month = aug,

day = "7",

doi = "10.1002/adhm.202304532",

language = "English",

volume = "13",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

publisher = "John Wiley \& Sons",

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AU - Chen, Zhenlin

AU - Fan, Lei

AU - Chen, Shuxun

AU - Zhao, Han

AU - Zhang, Qiang

AU - Qu, Yun

AU - Huang, Ya

AU - Yu, Xinge

AU - Sun, Dong

PY - 2024/8/7

Y1 - 2024/8/7

N2 - In vitro blood vessel models are significant for disease modeling, drug assays, and therapeutic development. Microfluidic technologies allow to create physiologically relevant culture models reproducing the features of the in vivo vascular microenvironment. However, current microfluidic technologies are limited by impractical rectangular cross-sections and single or nonsynchronous compound mechanical stimuli. This study proposes a new strategy for creating round-shaped deformable soft microfluidic channels to serve as artificial in vitro vasculature for developing in vitro models with vascular physio-mechanical microenvironments. Endothelial cells seeded into vascular models are used to assess the effects of a remodeled in vivo mechanical environment. Furthermore, a 3D stenosis model is constructed to recapitulate the flow disturbances in atherosclerosis. Soft microchannels can also be integrated into traditional microfluidics to realize multifunctional composite systems. This technology provides new insights into applying microfluidic chips and a prospective approach for constructing in vitro blood vessel models. © 2024 Wiley-VCH GmbH.

AB - In vitro blood vessel models are significant for disease modeling, drug assays, and therapeutic development. Microfluidic technologies allow to create physiologically relevant culture models reproducing the features of the in vivo vascular microenvironment. However, current microfluidic technologies are limited by impractical rectangular cross-sections and single or nonsynchronous compound mechanical stimuli. This study proposes a new strategy for creating round-shaped deformable soft microfluidic channels to serve as artificial in vitro vasculature for developing in vitro models with vascular physio-mechanical microenvironments. Endothelial cells seeded into vascular models are used to assess the effects of a remodeled in vivo mechanical environment. Furthermore, a 3D stenosis model is constructed to recapitulate the flow disturbances in atherosclerosis. Soft microchannels can also be integrated into traditional microfluidics to realize multifunctional composite systems. This technology provides new insights into applying microfluidic chips and a prospective approach for constructing in vitro blood vessel models. © 2024 Wiley-VCH GmbH.

KW - deformable microchannels

KW - environments

KW - mechanical

KW - microfluidics

KW - multiple stimulations

KW - vascular models

UR - https://www.scopus.com/pages/publications/85191174734

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85191174734&origin=recordpage

U2 - 10.1002/adhm.202304532

DO - 10.1002/adhm.202304532

M3 - RGC 21 - Publication in refereed journal

C2 - 38533604

SN - 2192-2640

VL - 13

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 20

M1 - 2304532

ER -

Artificial Vascular with Pressure-Responsive Property based on Deformable Microfluidic Channels

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Research Keywords

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GRF: High-throughput Robotic Microinjection System and Its Application in Constructing Gene-edited Macrophages with Enhanced Tumor-killing Ability

CRF: A Novel Vaccination Strategy: Using a Microrobot Platform for DNA Vaccine Delivery and Antigen Presentation

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Artificial Vascular with Pressure-Responsive Property based on Deformable Microfluidic Channels

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

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Projects

GRF: High-throughput Robotic Microinjection System and Its Application in Constructing Gene-edited Macrophages with Enhanced Tumor-killing Ability

CRF: A Novel Vaccination Strategy: Using a Microrobot Platform for DNA Vaccine Delivery and Antigen Presentation

Cite this