TY - JOUR
T1 - Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression
AU - Zhang, Jin-Fang
AU - He, Ming-Liang
AU - Dong, Qi
AU - Xie, Wei-Dong
AU - Chen, Yang-Chao
AU - Lin, Marie C. M.
AU - Leung, Ping-Chung
AU - Zhang, Ya-Ou
AU - Kung, Hsiang-Fu
PY - 2011/3
Y1 - 2011/3
N2 - Chemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. © The Author(s) 2011.
AB - Chemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. © The Author(s) 2011.
KW - apoptosis
KW - doxorubicin
KW - Fructus Ligustri Lucidi
KW - sensitivity
UR - http://www.scopus.com/inward/record.url?scp=79953728787&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-79953728787&origin=recordpage
U2 - 10.1177/1534735410373921
DO - 10.1177/1534735410373921
M3 - RGC 21 - Publication in refereed journal
C2 - 20702496
SN - 1534-7354
VL - 10
SP - 85
EP - 91
JO - Integrative Cancer Therapies
JF - Integrative Cancer Therapies
IS - 1
ER -
