Applications of Activity-Based Protein Profiling (ABPP) and Bioimaging in Drug Discovery

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Pages (from-to)34-41
Journal / PublicationChemistry - An Asian Journal
Issue number1
Online published24 Nov 2019
Publication statusPublished - 2 Jan 2020


Activity-based protein profiling (ABPP) and bioimaging have been developed in recent years as powerful technologies in drug discovery. Specifically, both approaches can be applied in critical steps of drug development, such as therapy target discovery, high-throughput drug screening and target identification of bioactive molecules. We have been focused on the development of various strategies that enable simultaneous activity-based protein profiling and bioimaging studies, thus facilitating an understanding of drug actions and potential toxicities. In this Minireview, we summarize these novel strategies and applications, with the aim of promoting these technologies in drug discovery.

Research Area(s)

  • ABPP, drug discovery, drug sceening, target discovery, target identification