Applications of Activity-Based Protein Profiling (ABPP) and Bioimaging in Drug Discovery
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Pages (from-to) | 34-41 |
Journal / Publication | Chemistry - An Asian Journal |
Volume | 15 |
Issue number | 1 |
Online published | 24 Nov 2019 |
Publication status | Published - 2 Jan 2020 |
Link(s)
Abstract
Activity-based protein profiling (ABPP) and bioimaging have been developed in recent years as powerful technologies in drug discovery. Specifically, both approaches can be applied in critical steps of drug development, such as therapy target discovery, high-throughput drug screening and target identification of bioactive molecules. We have been focused on the development of various strategies that enable simultaneous activity-based protein profiling and bioimaging studies, thus facilitating an understanding of drug actions and potential toxicities. In this Minireview, we summarize these novel strategies and applications, with the aim of promoting these technologies in drug discovery.
Research Area(s)
- ABPP, drug discovery, drug sceening, target discovery, target identification
Citation Format(s)
Applications of Activity-Based Protein Profiling (ABPP) and Bioimaging in Drug Discovery. / Xu, Jiaqian; Li, Xiaoqian; Ding, Ke et al.
In: Chemistry - An Asian Journal, Vol. 15, No. 1, 02.01.2020, p. 34-41.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review