Anti-Quenching NIR-II J-Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

24 Scopus Citations
View graph of relations

Author(s)

  • Yijian Gao
  • Wei-Chih Wei
  • Zhe Feng
  • Yuhuang Zhang
  • Ying Liu
  • Xiuli Zheng
  • Pengfei Wang
  • Shengliang Li
  • Ken-Tsung Wong
  • Chun-Sing Lee

Detail(s)

Original languageEnglish
Article number2211632
Journal / PublicationAdvanced Materials
Volume35
Issue number20
Online published31 Mar 2023
Publication statusPublished - 18 May 2023

Abstract

Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used to construct long-wavelength NIR-II emitters as their optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, their wide applications in the NIR-II fluorescence imaging are impeded by the limited varieties of J-type backbone and serious fluorescence quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) with anti-quenching effect is reported for highly efficient NIR-II bioimaging and phototheranostics. The BT fluorophores are manipulated to have Stokes shift over 400 nm and aggregation-induced emission (AIE) property for conquering the self-quenching issue of the J-type fluorophores. Upon forming BT6 assemblies in an aqueous environment, the absorption over 800 nm and NIR-II emission over 1000 nm are boosted for more than 41 and 26 folds, respectively. In vivo visualization of the whole-body blood vessel and imaging-guided phototherapy results verify that BT6 NPs are excellent agent for NIR-II fluorescence imaging and cancer phototheranostics. This work develops a strategy to construct bright NIR-II J-aggregates with precisely manipulated anti-quenching properties for highly efficient biomedical applications. © 2023 Wiley-VCH GmbH.

Research Area(s)

  • aggregation-induced emission, J-aggregates, large Stokes shift, molecular fluorophores, NIR-II fluorescence imaging, phototheranostics

Citation Format(s)

Anti-Quenching NIR-II J-Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics. / Lee, Ka-Wai; Gao, Yijian; Wei, Wei-Chih et al.
In: Advanced Materials, Vol. 35, No. 20, 2211632, 18.05.2023.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review