Antigenic Abnormalities in Fiber Tract Astrocytes of Myelin-Deficient Rats : An Immunocytochemical Study in the Olfactory Cortex

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)99-111
Journal / PublicationDevelopmental Neuroscience
Volume11
Issue number2
Online published13 Jun 1989
Publication statusPublished - 1989
Externally publishedYes

Abstract

Intrafascicular oligodendrocytes in myelin-deficient (md) rats typically fail to form myelin sheaths or survive to maturity. The present study of the md olfactory cortex compares astrocytes thai develop either among populations of pathological oligodendrocytes in a fiber tract or that develop in neuropil, which normally contains few oligodendrocytes. Antigenic profiles for md and normal astrocytes were defined by the monoclonal antibody Rat 401, and by antibodies that recognize vimentin and glial fibrillary acidic protein. In the olfactory cortex, antigenic abnormalities were typically restricted to astrocytes located in the vicinity of pathological oligodendrocytes. © 1989 S. Karger AG, Basel.

Research Area(s)

  • Astrocytes, Myelin-deftcient rats, Oligodendrocytes, Reactive astrocytes

Citation Format(s)