Antiferromagnetic Iron Nanocolloids : A New Generation in Vivo T1 MRI Contrast Agent

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

49 Scopus Citations
View graph of relations

Author(s)

  • Chien-Liang Liu
  • Hsieh-Chih Chen
  • Shang-Wei Chou
  • Wei-Hsuan Tseng
  • Yu-Jui Tseng
  • Chia-Cheng Kang
  • Jong-Kai Hsiao
  • Pi-Tai Chou

Detail(s)

Original languageEnglish
Pages (from-to)18621-18628
Journal / PublicationJournal of the American Chemical Society
Volume135
Issue number49
Online published20 Nov 2013
Publication statusPublished - 11 Dec 2013
Externally publishedYes

Abstract

A novel T1 agent, antiferromagnetic α-iron oxide-hydroxide (α-FeOOH) nanocolloids with a diameter of 2-3 nm, has been successfully prepared. These nanocolloids, together with a post synthetic strategy performed in mesoporous silica, are a great improvement over the low T1- weighted contrast common in traditional magnetic silica nanocomposites. The intrinsic antiferromagnetic goethite (α-FeOOH) shows very low magnetization (Mz) of 0.05 emu g-1 at H = 2 T at 300 K (0.0006 emu g-1 for FeOOH/WMSN-PEG), which is 2 orders of magnitude smaller than any current ultrasmall iron oxide NPs (>5 emu g-1) reported to date, hence ensuring the low r2 (α Mz) (7.64 mM-1 s-1) and r2/r1 ratio (2.03) at 4.7 T. These biodegradable α-FeOOH nanocolloids also demonstrate excellent in vitro cellular imaging and in vivo MR vascular and urinary trace imaging capability with outstanding biocompatibility, which is exceptionally well secreted by the kidney and not the liver as with most nanoparticles, opening up a new avenue for designing powerful antiferromagnetic iron T1 contrast agents.

Citation Format(s)

Antiferromagnetic Iron Nanocolloids : A New Generation in Vivo T1 MRI Contrast Agent. / Peng, Yung-Kang; Liu, Chien-Liang; Chen, Hsieh-Chih et al.

In: Journal of the American Chemical Society, Vol. 135, No. 49, 11.12.2013, p. 18621-18628.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review