Antibacterial polyetheretherketone micro/nanoarrays with enhanced cell proliferation properties

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)peer-review

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Detail(s)

Original languageEnglish
Publication statusPublished - Aug 2019

Conference

Title2019 Chinese Biomaterials Congress & International Symposium on Advanced Biomaterials
LocationDalian World Expo Center
PlaceChina
CityDalian
Period22 - 25 August 2019

Abstract

Introduction: A good implant material should possess antibacterial ability to avoid infection and improve cell adhesion and proliferation to facilitate wound healing after surgery. Polyetheretherketone (PEEK) has been widely studied as biomaterials for implant, due to its excellent mechanical properties. Although many approaches such as sulfonation have been developed to modify the bioinert and hydrophobic properties of PEEK. However, the composition and the related properties of PEEK are also changed. The micro/nano arrays designed in this work can kill the bacteria effectively without the release of any harmful species and the significant change of the beneficial properties of PEEK. 

Materials & Methods: A range of PEEK micro/nanoarrays were successfully fabricated by combining colloidal lithography with reactive ion etching. Bacterial resistance abilities of these arrays were evaluated by spread plate method and live/dead staining. Also, the cytotoxicity was conducted through MTT assay and the observed under SEM. 

Results & Discussion: The antimicrobial tests of these arrays revealed that the shape and the dimension of these arrays result in the remarkable difference in their antibacterial abilities, and the microarray PEEK had an excellent resistance for E. coli at different periods. Also, the superhydrophilic property of the array facilitates the adhesion and growth of preosteoblasts on the surface of PEEK, compared with the virgin PEEK. Unfortunately, the array can kill specific bacteria, which was similar to the cicada wing. 

Conclusions: These results demonstrate that the fabrication of microarray on the surface of PEEK is a promising way to make PEEK as a better candidate for orthopedic implant materials.

Research Area(s)

  • Antibacterial surface, biomaterials, microarray, polyetheretherketone

Citation Format(s)

Antibacterial polyetheretherketone micro/nanoarrays with enhanced cell proliferation properties. / Mo, Shi; Mehrjou, Babak; Wang, Guomin; Tang, Kaiwei; Huo, Kaifu; Chu, Paul K.

2019. Paper presented at 2019 Chinese Biomaterials Congress & International Symposium on Advanced Biomaterials, Dalian, China.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)peer-review