Analysis of the material properties of early chondrogenic differentiated adipose-derived stromal cells (ASC) using an in vitro three-dimensional micromass culture system
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 311-316 |
Journal / Publication | Biochemical and Biophysical Research Communications |
Volume | 359 |
Issue number | 2 |
Online published | 25 May 2007 |
Publication status | Published - 27 Jul 2007 |
Externally published | Yes |
Link(s)
Abstract
Cartilage is an avascular tissue with only a limited potential to heal and chondrocytes in vitro have poor proliferative capacity. Recently, adipose-derived stromal cells (ASC) have demonstrated a great potential for application to tissue engineering due to their ability to differentiate into cartilage, bone, and fat. In this study, we have utilized a high density three-dimensional (3D) micromass model system of early chondrogenesis with ASC. The material properties of these micromasses showed a significant increase in dynamic and static elastic modulus during the early chondrogenic differentiation process. These data suggest that the 3D micromass culture system represents an in vitro model of early chondrogenesis with dynamic cell signaling interactions associated with the mechanical properties of chondrocyte differentiation.
Research Area(s)
- Cartilage repair, Chondrocyte, High density culture, Mechanical property, Mesenchymal stem cells, Nanoindentation, Tissue regeneration
Citation Format(s)
Analysis of the material properties of early chondrogenic differentiated adipose-derived stromal cells (ASC) using an in vitro three-dimensional micromass culture system. / Xu, Yue; Balooch, Guive; Chiou, Michael et al.
In: Biochemical and Biophysical Research Communications, Vol. 359, No. 2, 27.07.2007, p. 311-316.
In: Biochemical and Biophysical Research Communications, Vol. 359, No. 2, 27.07.2007, p. 311-316.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review