Anaerobic function of CNS white matter declineswith age

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)996-1002
Journal / PublicationJournal of Cerebral Blood Flow and Metabolism
Volume31
Issue number4
Online published22 Dec 2010
Publication statusPublished - Apr 2011
Externally publishedYes

Abstract

The mammalian central nervous system (CNS) is generally believed to be completely dependent on the presence of oxygen (O2) to maintain energy levels necessary for excitability. However, previous studies on CNS white matter (WM) have shown that a large subset of CNS-myelinated axons of mice aged 4 to 6 weeks remains excitable in the absence of O2. We investigated whether this surprising WM tolerance to anoxia varied with age. Acutely isolated mouse optic nerve (MON), a purely myelinated WM tract, was studied electrophysiologically. Excitability in the MONs from 1-month-, 4-month-, and 8-month-old mice was assessed quantitatively as the area under the supramaximal compound action potential (CAP). Anoxia-resistant WM function declined with age. After 60 minutes of anoxia, ∼23% of the CAP remained in 1-month-old mice, 8% in 4-month-old mice, and ∼0 in the 8-month-old group. Our results indicated that although some CNS axons function anaerobically in young adult animals, they lose this ability in later adulthood. This finding may help explain the clinical impression that favorable outcome after stroke and other brain injuries declines with age. © 2011 ISCBFM All rights reserved.

Research Area(s)

  • anoxia, CNS axon, cyanide, energy metabolism, glycolysis

Citation Format(s)

Anaerobic function of CNS white matter declineswith age. / Hamner, Margaret A.; Möller, Thomas; Ransom, Bruce R.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 4, 04.2011, p. 996-1002.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review