An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells

Qinya Duan; Guansheng Zheng; Zejun Li; Ke Cheng; Jie Zhang; Liu Yang; Yin Jiang; Huatang Zhang; Jun He; Hongyan Sun

doi:10.1039/c9tb01279f

Author(s)

Qinya Duan
Guansheng Zheng
Zejun Li
Yin Jiang
Huatang Zhang
Jun He

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	5125-5131
Journal / Publication	Journal of Materials Chemistry B
Volume	7
Issue number	33
Online published	20 Jul 2019
Publication status	Published - 7 Sept 2019

Link(s)

DOI	DOI https://doi.org/10.1039/c9tb01279f Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85071230679&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(c766686c-6f82-46ba-9548-d8f32d6e2371).html

Abstract

An ultra-sensitive and ratiometric fluorescent probe for hypochlorous acid (HOCl) detection based on the mechanism of aggregation induced emission (AIE) and through-bond energy transfer (TBET) has been reported herein. By exploiting the advantages of AIE and TBET, which eliminates emission leakage from dark donors, the probe exhibits ultra-high sensitivity towards HOCl by an enhancement of over 7000-fold in the fluorescence ratio (I_589 nm/I_477 nm), which is one of the highest recorded so far. The reaction mechanism has been discussed in detail, and the effects of interferents and the reaction kinetics have also been investigated. Lastly, the successful result of exogenous/endogenous HOCl imaging detection in different cell lines indicates the potential use of the probe in living systems.

Citation Format(s)

[ RIS ] [ BibTeX ]

An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells. / Duan, Qinya; Zheng, Guansheng; Li, Zejun et al.
In: Journal of Materials Chemistry B, Vol. 7, No. 33, 07.09.2019, p. 5125-5131.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Duan, Q, Zheng, G, Li, Z, Cheng, K , Zhang, J , Yang, L, Jiang, Y, Zhang, H, He, J & Sun, H 2019, 'An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells', Journal of Materials Chemistry B, vol. 7, no. 33, pp. 5125-5131. https://doi.org/10.1039/c9tb01279f

Duan, Q., Zheng, G., Li, Z., Cheng, K., Zhang, J., Yang, L., Jiang, Y., Zhang, H., He, J., & Sun, H. (2019). An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells. Journal of Materials Chemistry B, 7(33), 5125-5131. Advance online publication. https://doi.org/10.1039/c9tb01279f

Duan Q, Zheng G, Li Z, Cheng K , Zhang J , Yang L et al. An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells. Journal of Materials Chemistry B. 2019 Sept 7;7(33):5125-5131. Epub 2019 Jul 20. doi: 10.1039/c9tb01279f

Duan, Qinya ; Zheng, Guansheng ; Li, Zejun et al. / An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells. In: Journal of Materials Chemistry B. 2019 ; Vol. 7, No. 33. pp. 5125-5131.