An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

49 authors, including; Yuqiong Wang; Lamei Du; Han Wu; Hu Li; Jiaqi Liu; Yongyan Hu; Yawen Yang; Jingkun Zhou; Denglin Ye; Kuanming Yao; Xinge Yu; Yubo Fan; Cunjiang Yu; Ye Xu; Lingqian Chang

doi:10.1016/j.cell.2025.12.021

An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

49 authors, including
, Yuqiong Wang (Co-first Author)
, Lamei Du (Co-first Author)
, Han Wu (Co-first Author)
, Hu Li (Co-first Author)
, Jiaqi Liu (Co-first Author)
, Yongyan Hu (Co-first Author)
, Yawen Yang
, Jingkun Zhou
, Denglin Ye
, Kuanming Yao
, Xinge Yu^*
, Yubo Fan^*
, Cunjiang Yu^*
, Ye Xu^*
, Lingqian Chang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

8 Citations (Scopus)

Abstract

Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties. Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features high conformality enabled by parametric customization, achieving a theoretically maximum effective coverage area over the target organ. The four-layered POCKET forms a unique nanopore-cell juxtaposition configuration at the tissue-device interface, which induces precise, uniform electro-perforation while expediting intracellular transport of payloads. The high delivery efficiency and precise spatial controllability have been systematically validated with various organs. POCKET-mediated therapeutic delivery achieved organ protection from accumulated DNA damage or ischemia-reperfusion injury, restoring organ functionalities. This work presents a customizable technique with translational value for precise therapy in challenging target organs. © 2025 Elsevier Inc.

Original language	English
Pages (from-to)	1086-1107.e32
Number of pages	54
Journal	Cell
Volume	189
Issue number	4
Online published	27 Jan 2026
DOIs	https://doi.org/10.1016/j.cell.2025.12.021
Publication status	Published - 19 Feb 2026

Funding

We sincerely thank Dr. Shengsong Ou, Dr. Yisen Deng, and Dr. Changyu Ma for their technical support and guidance in porcine laparoscopic surgery. We are grateful to Prof. Zhaojian Liu and Prof. Hongbin Liu for their guidance in germline safety validation and Dr. Weijian Yao for his advice on optimizing the IRI mouse model. We also thank Prof. Zhaogang Sun for his generous contribution of Staphylococcus aureus. This work was supported by the National Science Fund for Distinguished Young Scholars (no. T2425021), the National Natural Science Foundation of China (nos. 62471021, 12072010, T24B2006, and U23A20363), the National Key Research and Development Program of China (2022YFB3205601 and 2023YFC2415900), the Fundamental Research Funds for the Central Universities (JKF-20240574, YWF-22-K-101, D5000250233, and GW2025-ZY-04), the Research Grants Council of the Hong Kong Special Administrative Region (nos. RFS2324-1S03 and R1017-24F), the Beijing United Fund (no. L252063), and the CAMS Innovation Fund for Medical Sciences (grant no. 2021-I2M-1-014).

Research Keywords

bioelectronic pach
conformality
electro-transfection
electroporation
intracellular delivery
ischemia-reperfusion injury
kirigami
ovary gene therapy

RGC Funding Information

RGC-funded

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@article{3e0b0c6811ca4a1496fe0ed379474f94,

title = "An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery",

abstract = "Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties. Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features high conformality enabled by parametric customization, achieving a theoretically maximum effective coverage area over the target organ. The four-layered POCKET forms a unique nanopore-cell juxtaposition configuration at the tissue-device interface, which induces precise, uniform electro-perforation while expediting intracellular transport of payloads. The high delivery efficiency and precise spatial controllability have been systematically validated with various organs. POCKET-mediated therapeutic delivery achieved organ protection from accumulated DNA damage or ischemia-reperfusion injury, restoring organ functionalities. This work presents a customizable technique with translational value for precise therapy in challenging target organs. {\textcopyright} 2025 Elsevier Inc.",

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year = "2026",

month = feb,

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doi = "10.1016/j.cell.2025.12.021",

language = "English",

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pages = "1086--1107.e32",

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T1 - An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

AU - 49 authors, including

AU - Wang, Yuqiong

AU - Du, Lamei

AU - Wu, Han

AU - Li, Hu

AU - Liu, Jiaqi

AU - Hu, Yongyan

AU - Jiang, Xinran

AU - Yin, Dedong

AU - Hao, Yongcun

AU - Xiao, Ao

AU - Yang, Yawen

AU - Zhou, Jingkun

AU - Lin, Long

AU - Chen, Feng

AU - Ye, Denglin

AU - He, Yuhui

AU - Zhao, Zhixiong

AU - Liu, Baoyu

AU - Yao, Kuanming

AU - Wang, Xiaohong

AU - Chen, Xi

AU - Tong, Yihang

AU - Yao, Fuqi

AU - Yang, Kuan

AU - Sun, Hong

AU - Fu, Yanzhe

AU - Wang, Siqi

AU - Huang, Zhaocun

AU - Chen, Xinyi

AU - Guo, Hao

AU - Kong, Shenshen

AU - Yang, Shaohua

AU - Song, Wenjing

AU - Ershad, Faheem

AU - Wang, Yang

AU - Zhang, Li

AU - Zhang, Qiuting

AU - Wu, Hao

AU - Li, Ning

AU - Rao, Wei

AU - Li, Jiebo

AU - Yang, Li

AU - Chen, Xing

AU - Mu, Wei

AU - Yu, Xinge

AU - Fan, Yubo

AU - Yu, Cunjiang

AU - Xu, Ye

AU - Chang, Lingqian

PY - 2026/2/19

Y1 - 2026/2/19

N2 - Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties. Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features high conformality enabled by parametric customization, achieving a theoretically maximum effective coverage area over the target organ. The four-layered POCKET forms a unique nanopore-cell juxtaposition configuration at the tissue-device interface, which induces precise, uniform electro-perforation while expediting intracellular transport of payloads. The high delivery efficiency and precise spatial controllability have been systematically validated with various organs. POCKET-mediated therapeutic delivery achieved organ protection from accumulated DNA damage or ischemia-reperfusion injury, restoring organ functionalities. This work presents a customizable technique with translational value for precise therapy in challenging target organs. © 2025 Elsevier Inc.

AB - Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties. Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features high conformality enabled by parametric customization, achieving a theoretically maximum effective coverage area over the target organ. The four-layered POCKET forms a unique nanopore-cell juxtaposition configuration at the tissue-device interface, which induces precise, uniform electro-perforation while expediting intracellular transport of payloads. The high delivery efficiency and precise spatial controllability have been systematically validated with various organs. POCKET-mediated therapeutic delivery achieved organ protection from accumulated DNA damage or ischemia-reperfusion injury, restoring organ functionalities. This work presents a customizable technique with translational value for precise therapy in challenging target organs. © 2025 Elsevier Inc.

KW - bioelectronic pach

KW - conformality

KW - electro-transfection

KW - electroporation

KW - intracellular delivery

KW - ischemia-reperfusion injury

KW - kirigami

KW - ovary gene therapy

UR - https://www.scopus.com/pages/publications/105029751884

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-105029751884&origin=recordpage

U2 - 10.1016/j.cell.2025.12.021

DO - 10.1016/j.cell.2025.12.021

M3 - RGC 21 - Publication in refereed journal

C2 - 41605209

SN - 0092-8674

VL - 189

SP - 1086-1107.e32

JO - Cell

JF - Cell

IS - 4

ER -

An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

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Research Keywords

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RIF: Thin, Soft, Wireless, Air and Sweat Permeable Electronics for Long Term ECG Monitoring

RIF-Sub-pj: Thin, Soft, Wireless, Air and Sweat Permeable Electronics for Long Term ECG Monitoring

RFS: Skin-Integrated and Multi-functional Closed Loop Human Machine Interface: Sensing, Actuation, and System Integration

Cite this

An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

Abstract

Funding

Research Keywords

RGC Funding Information

Access Output

Other Access Options

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Other Files and Links

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Projects

RIF: Thin, Soft, Wireless, Air and Sweat Permeable Electronics for Long Term ECG Monitoring

RIF-Sub-pj: Thin, Soft, Wireless, Air and Sweat Permeable Electronics for Long Term ECG Monitoring

RFS: Skin-Integrated and Multi-functional Closed Loop Human Machine Interface: Sensing, Actuation, and System Integration

Cite this