An iterative neural processing sequence orchestrates feeding

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

5 Scopus Citations
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Author(s)

  • Qingqing Liu
  • Xing Yang
  • Junying Su
  • Jinling Zhong
  • Xiaofen Li
  • Liping Wang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)1651-1665.e5
Journal / PublicationNeuron
Volume111
Issue number10
Online published15 Mar 2023
Publication statusPublished - 17 May 2023

Link(s)

Abstract

Feeding requires sophisticated orchestration of neural processes to satiate appetite in natural, capricious settings. However, the complementary roles of discrete neural populations in orchestrating distinct behaviors and motivations throughout the feeding process are largely unknown. Here, we delineate the behavioral repertoire of mice by developing a machine-learning-assisted behavior tracking system and show that feeding is fragmented and divergent motivations for food consumption or environment exploration compete throughout the feeding process. An iterative activation sequence of agouti-related peptide (AgRP)-expressing neurons in arcuate (ARC) nucleus, GABAergic neurons in the lateral hypothalamus (LH), and in dorsal raphe (DR) orchestrate the preparation, initiation, and maintenance of feeding segments, respectively, via the resolution of motivational conflicts. The iterative neural processing sequence underlying the competition of divergent motivations further suggests a general rule for optimizing goal-directed behaviors. © 2023 The Authors.

Research Area(s)

  • AgRP neuron, appetite, behavior identification, dorsal raphe, eating disorder, feeding initiation, feeding maintenance, food consumption, lateral hypothalamus, motivation competition

Citation Format(s)

An iterative neural processing sequence orchestrates feeding. / Liu, Qingqing; Yang, Xing; Luo, Moxuan et al.
In: Neuron, Vol. 111, No. 10, 17.05.2023, p. 1651-1665.e5.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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