An Iridium (III) Complex Bearing a Donor–Acceptor–Donor Type Ligand for NIR-Triggered Dual Phototherapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jian Zhao
  • Kaiwen Yan
  • Gang Xu
  • Xue Liu
  • Qiang Zhao
  • Shaohua Gou

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number2008325
Journal / PublicationAdvanced Functional Materials
Volume31
Issue number11
Online published23 Dec 2020
Publication statusPublished - 10 Mar 2021

Abstract

Iridium(III) complexes are an important group of photosensitizers for photodynamic therapy (PDT). This work constructs a donor–acceptor–donor structure-based iridium(III) complex (IrDAD) with high reactive oxygen species (ROS) generation efficiency, negligible dark toxicity, and synergistic PDT and photothermal therapy (PTT) effect under near-infrared (NIR) stimulation. This complex self-assembles into metallosupramolecular aggregates with a unique aggregation-induced PDT behavior. Compared with conventional iridium(III) photosensitizers, IrDAD not only achieves NIR light deep tissue penetration but also shows highly efficient ROS and heat generation with ROS quantum yield of 14.6% and photothermal conversion efficiency of 27.5%. After conjugation with polyethylene glycol (PEG), IrDAD is formulated to a nanoparticulate system (IrDAD-NPs) with good solubility. In cancer phototherapy, IrDAD-NPs preferentially accumulate in tumor area and display a significant tumor inhibition in vivo, with 96% reduction in tumor volume, and even tumor elimination.

Research Area(s)

  • cancer therapy, donor–acceptor ligand, iridium complex, photodynamic therapy, photothermal therapy

Citation Format(s)

An Iridium (III) Complex Bearing a Donor–Acceptor–Donor Type Ligand for NIR-Triggered Dual Phototherapy. / Zhao, Jian; Yan, Kaiwen; Xu, Gang; Liu, Xue; Zhao, Qiang; Xu, Chenjie; Gou, Shaohua.

In: Advanced Functional Materials, Vol. 31, No. 11, 2008325, 10.03.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review