An intranucleolar body associated with rDNA

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Saskia Hutten
  • Alan Prescott
  • John James
  • Stefanie Riesenberg
  • Séverine Boulon
  • Angus I. Lamond

Detail(s)

Original languageEnglish
Pages (from-to)481-499
Journal / PublicationChromosoma
Volume120
Issue number5
Publication statusPublished - Oct 2011

Link(s)

Abstract

The nucleolus is the subnuclear organelle responsible for ribosome subunit biogenesis and can also act as a stress sensor. It forms around clusters of ribosomal DNA (rDNA) and is mainly organised in three subcompartments, i.e. fibrillar centre, dense fibrillar component and granular component. Here, we describe the localisation of 21 protein factors to an intranucleolar region different to these main subcompartments, called the intranucleolar body (INB). These factors include proteins involved in DNA maintenance, protein turnover, RNA metabolism, chromatin organisation and the post-translational modifiers SUMO1 and SUMO2/3. Increase in the size and number of INBs is promoted by specific types of DNA damage and depends on the functional integrity of the nucleolus. INBs are abundant in nucleoli of unstressed cells during S phase and localise in close proximity to rDNA with heterochromatic features. The data suggest the INB is linked with regulation of rDNA transcription and/or maintenance of rDNA. © 2011 The Author(s).

Research Area(s)

Citation Format(s)

An intranucleolar body associated with rDNA. / Hutten, Saskia; Prescott, Alan; James, John; Riesenberg, Stefanie; Boulon, Séverine; Lam, Yun Wah; Lamond, Angus I.

In: Chromosoma, Vol. 120, No. 5, 10.2011, p. 481-499.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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