An IncR Pplasmid Harbored by a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Possesses Five Tandem Repeats of the blaKPC-2::NTEKPC-Id Fragment

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Ning Dong
  • Lizhang Liu
  • Rong Zhang
  • Kaichao Chen
  • Edward Wai Chi Chan

Detail(s)

Original languageEnglish
Article numbere01775-18
Journal / PublicationAntimicrobial Agents and Chemotherapy
Volume63
Issue number3
Online published26 Feb 2019
Publication statusPublished - Mar 2019
Externally publishedYes

Abstract

Completed sequences of three plasmids from a carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate, SH9, were obtained. In addition to the pLVPK-like virulence-conferring plasmid (pVir-CR-HvKP_SH9), the two multidrug-resistant plasmids (pKPC-CR-HvKP4_SH9 and pCTX-M-CR-HvKP4_SH9) were predicted to originate from a single pKPC-CR-HvKP4-like multireplicon plasmid through homologous recombination. Interestingly, the blaKPC-2 gene was detectable in five tandem repeats exhibiting the format of an NTEKPC-Id-like transposon (IS26-ΔTn3-ISKpn8-blaKPC-2-ΔISKpn6-korC-orf-IS26). The data suggest an important role of DNA recombination in mediating active plasmid evolution.

Research Area(s)

  • BlaKPC-2, Cointegration, Hypervirulent, Klebsiella pneumoniae, Tandem repeat

Citation Format(s)

An IncR Pplasmid Harbored by a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Possesses Five Tandem Repeats of the blaKPC-2::NTEKPC-Id Fragment. / Dong, Ning; Liu, Lizhang; Zhang, Rong; Chen, Kaichao; Xie, Miaomiao; Chan, Edward Wai Chi; Chen, Sheng.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 3, e01775-18, 03.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal