An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection

Yu- Fang Lee; Kang-Yi Lien; Huan-Yao Lei; Ruo-Chi Hsu; Gwo-Bin Lee

doi:10.1109/NEMS.2010.5592423

An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection

Yu- Fang Lee
, Kang-Yi Lien
, Huan-Yao Lei
, Ruo-Chi Hsu
, Gwo-Bin Lee^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

The paper presents a new immunomagnetic-bead-based microfluidic system integrated with an optical detection module for rapid diagnosis of influenza infection. By using the immunomagnetic beads conjugated with influenza-specific antibodies, the developed system can detect influenza viral particles with a high sensitivity and specificity while compared with large-scale systems. The viral particles were firstly recognized and adhered onto the surface of the magnetic beads, then incubated with the developing antibodies labeled with fluorescent dye, and finally detected optically. The developed micro system can perform automatic mixing, transportation and detection of influenza virus within a short period of time and could lead to a crucial platform for biological and medical applications. ©2010 IEEE.

Original language	English
Title of host publication	2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
Pages	421-424
DOIs	https://doi.org/10.1109/NEMS.2010.5592423
Publication status	Published - 2010
Externally published	Yes
Event	5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010) - Xiamen, China Duration: 20 Jan 2010 → 23 Jan 2010

Publication series

Name	2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010

Conference

Conference	5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010)
Abbreviated title	IEEE-NEMS 2010
Place	China
City	Xiamen
Period	20/01/10 → 23/01/10

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Fluorescent detection
Immunoassay
Influenza infection
Magnetic bead
MEMS
Microfluidics

Access Output

10.1109/NEMS.2010.5592423

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

Lee, Y. F., Lien, K.-Y., Lei, H.-Y., Hsu, R.-C., & Lee, G.-B. (2010). An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection. In 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 (pp. 421-424). Article 5592423 (2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010). https://doi.org/10.1109/NEMS.2010.5592423

@inproceedings{c48949a6f26c46579113c69f7d555576,

title = "An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection",

abstract = "The paper presents a new immunomagnetic-bead-based microfluidic system integrated with an optical detection module for rapid diagnosis of influenza infection. By using the immunomagnetic beads conjugated with influenza-specific antibodies, the developed system can detect influenza viral particles with a high sensitivity and specificity while compared with large-scale systems. The viral particles were firstly recognized and adhered onto the surface of the magnetic beads, then incubated with the developing antibodies labeled with fluorescent dye, and finally detected optically. The developed micro system can perform automatic mixing, transportation and detection of influenza virus within a short period of time and could lead to a crucial platform for biological and medical applications. {\textcopyright}2010 IEEE.",

keywords = "Fluorescent detection, Immunoassay, Influenza infection, Magnetic bead, MEMS, Microfluidics",

author = "Lee, \{Yu- Fang\} and Kang-Yi Lien and Huan-Yao Lei and Ruo-Chi Hsu and Gwo-Bin Lee",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].; 5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010), IEEE-NEMS 2010 ; Conference date: 20-01-2010 Through 23-01-2010",

year = "2010",

doi = "10.1109/NEMS.2010.5592423",

language = "English",

isbn = "9781424465439",

series = "2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010",

pages = "421--424",

booktitle = "2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010",

}

Lee, YF, Lien, K-Y, Lei, H-Y, Hsu, R-C & Lee, G-B 2010, An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection. in 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010., 5592423, 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010, pp. 421-424, 5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010), Xiamen, China, 20/01/10. https://doi.org/10.1109/NEMS.2010.5592423

An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection. / Lee, Yu- Fang; Lien, Kang-Yi; Lei, Huan-Yao et al.
2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010. 2010. p. 421-424 5592423 (2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection

AU - Lee, Yu- Fang

AU - Lien, Kang-Yi

AU - Lei, Huan-Yao

AU - Hsu, Ruo-Chi

AU - Lee, Gwo-Bin

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2010

Y1 - 2010

N2 - The paper presents a new immunomagnetic-bead-based microfluidic system integrated with an optical detection module for rapid diagnosis of influenza infection. By using the immunomagnetic beads conjugated with influenza-specific antibodies, the developed system can detect influenza viral particles with a high sensitivity and specificity while compared with large-scale systems. The viral particles were firstly recognized and adhered onto the surface of the magnetic beads, then incubated with the developing antibodies labeled with fluorescent dye, and finally detected optically. The developed micro system can perform automatic mixing, transportation and detection of influenza virus within a short period of time and could lead to a crucial platform for biological and medical applications. ©2010 IEEE.

AB - The paper presents a new immunomagnetic-bead-based microfluidic system integrated with an optical detection module for rapid diagnosis of influenza infection. By using the immunomagnetic beads conjugated with influenza-specific antibodies, the developed system can detect influenza viral particles with a high sensitivity and specificity while compared with large-scale systems. The viral particles were firstly recognized and adhered onto the surface of the magnetic beads, then incubated with the developing antibodies labeled with fluorescent dye, and finally detected optically. The developed micro system can perform automatic mixing, transportation and detection of influenza virus within a short period of time and could lead to a crucial platform for biological and medical applications. ©2010 IEEE.

KW - Fluorescent detection

KW - Immunoassay

KW - Influenza infection

KW - Magnetic bead

KW - MEMS

KW - Microfluidics

UR - https://www.scopus.com/pages/publications/78649244820

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-78649244820&origin=recordpage

U2 - 10.1109/NEMS.2010.5592423

DO - 10.1109/NEMS.2010.5592423

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781424465439

T3 - 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010

SP - 421

EP - 424

BT - 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010

T2 - 5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010)

Y2 - 20 January 2010 through 23 January 2010

ER -

Lee YF, Lien KY, Lei HY, Hsu RC, Lee GB. An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection. In 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010. 2010. p. 421-424. 5592423. (2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010). doi: 10.1109/NEMS.2010.5592423

An immunomagnetic-bead-based microfluidic system for rapid diagnosis of influenza infection

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Research Keywords

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this